Piperazine, 1,4-diacetyl-

Base Information

• Chemical Name: Piperazine, 1,4-diacetyl-
• CAS No.: 18940-57-3
• Molecular Formula: C8H14N2O2
• Molecular Weight: 170.211
• Hs Code.: 2933599090
• NSC Number: 54822,39650
• UNII: G95A229PEK
• DSSTox Substance ID: DTXSID00172352
• Nikkaji Number: J50.583H
• Wikidata: Q83042453
• Mol file: 18940-57-3.mol

Synonyms:1,1'-(Piperazine-1,4-diyl)diethanone;18940-57-3;Piperazine, 1,4-diacetyl-;1,4-Diacetylpiperazine;1-(4-acetylpiperazin-1-yl)ethanone;AI3-28700;NSC 39650;BRN 0136055;G95A229PEK;NSC-39650;Piperazine,4-diacetyl-;Ethanone, 1,1'-(1,4-piperazinediyl)bis-;Piperazine, 1,4-diacetyl- (6CI,8CI,9CI);5-23-01-00045 (Beilstein Handbook Reference);NSC39650;UNII-G95A229PEK;SCHEMBL860793;DTXSID00172352;AMY10038;NSC54822;NSC-54822;AKOS003888568;Benzylpiperazine-M (piperazine), 2AC;DS-17612;Piperazine,1,4-diacetyl-(6ci,8ci,9ci);1,1'-(1,4-Piperazinediyl)bis[ethanone];LS-111444;CS-0155035;O10329;A880452;Z31727122

Chemical Property of Piperazine, 1,4-diacetyl-

Chemical Property:

• Vapor Pressure: 1.6E-05mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 365.2 °C at 760 mmHg
• Flash Point: 177.6 °C
• PSA: 40.62000
• Density: 1.126 g/cm³
• LogP: -0.42720
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 170.105527694
• Heavy Atom Count: 12
• Complexity: 173

Purity/Quality:

99% ^*data from raw suppliers

1,1''-(Piperazine-1,4-diyl)diethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N1CCN(CC1)C(=O)C

Technology Process of Piperazine, 1,4-diacetyl-

There total 3 articles about Piperazine, 1,4-diacetyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-Acetylimidazole (2466-76-4) + piperazine dihydrochloride (142-64-3,8006-71-1) → N-acetylpiperidine (13889-98-0) + 1,4-diacetylpiperazine (18940-57-3)

Guidance literature:

In ethanol; water; at 20 ℃; for 6.16667h;

DOI:10.1021/ol101604q

Reference yield:

piperazine (110-85-0) + N-Acetylimidazole (2466-76-4) + piperazine dihydrochloride (142-64-3,8006-71-1) → N-acetylpiperidine (13889-98-0) + 1,4-diacetylpiperazine (18940-57-3)

Guidance literature:

piperazine; piperazine dihydrochloride; In water; for 0.0833333h;

N-Acetylimidazole; With sodium chloride; In water; for 0.5h;

With sodium hydroxide; In water; chemoselective reaction;

DOI:10.1039/c1gc16314k

Reference yield:

piperazine (110-85-0) + acetic acid (64-19-7,77671-22-8) → N-acetylpiperidine (13889-98-0) + 1,4-diacetylpiperazine (18940-57-3)

Guidance literature:

at 130 ℃; for 1h; microwave irradiation;

DOI:10.1016/j.tetlet.2008.02.170

upstream raw materials:

piperazine

acetic acid

N-Acetylimidazole

piperazine dihydrochloride

Downstream raw materials:

1,4-dinitropiperazine

1,4-diethylpiperazine

Refernces

• 1、 Verma, Sanjeev K.,Acharya,Kaushik. "Imidazole-catalyzed monoacylation of symmetrical diamines". supporting information; experimental part. p. 4232 - 4235. Retrieved 2010/11/04.