2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone

Base Information

• Chemical Name: 2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone
• CAS No.: 103281-33-0
• Molecular Formula: C28H24O3
• Molecular Weight: 408.497
• Mol file: 103281-33-0.mol

Synonyms:2,2-Bis(4-Methoxyphenyl)-1,2-diphenylethanone;2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone

Chemical Property of 2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone

Chemical Property:

• PSA: 35.53000
• LogP: 5.92110
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Methanol

Purity/Quality:

98% ^*data from raw suppliers

2,2-Bis(4-methoxyphenyl)-1,2-diphenylethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of Clomiphene (C587025) impurity.

Technology Process of 2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone

There total 9 articles about 2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-hydroxy-2-(4-methoxyphenyl)-1,2-diphenylethanone (367935-16-8) + methoxybenzene (100-66-3) → 2,2-bis-(p-methoxyphenyl)-1,2-diphenylethanone (103281-33-0)

Guidance literature:

With perchloric acid; In nitromethane; at 60 ℃; for 26h;

DOI:10.1002/asia.201200693

Reference yield: 46.0%

2-hydroxy-2-(4-methoxyphenyl)-1,2-diphenylethanone (367935-16-8) + methoxybenzene (100-66-3) → 2,2-bis-(p-methoxyphenyl)-1,2-diphenylethanone (103281-33-0) + 6-methoxy-2,3-diphenylbenzo[b]furan (14770-94-6)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 25 ℃; for 0.166667h; Green chemistry;

DOI:10.1002/ejoc.201403438

Reference yield:

1,2-bis(4-methoxyphenyl)-1,2-diphenyl-1,2-ethanediol (2443-45-0) → 2,2-bis-(p-methoxyphenyl)-1,2-diphenylethanone (103281-33-0)

Guidance literature:

With sulfuric acid;

upstream raw materials:

4-Methoxybenzophenone

1,2-bis(4-methoxyphenyl)-1,2-diphenyl-1,2-ethanediol

1-(4-methoxyphenyl)-1-phenylmethanol

1,2-bis(4-methoxyphenyl)-1,2-ethanedione

Downstream raw materials:

4,4'-dimethoxytriphenylmethane

benzoic acid

4,4'-dimethoxytrityl alcohol

2,2-bis-(4-methoxy-phenyl)-1,2-diphenyl-ethanol

Refernces

• 1、 Kumar, Anil,Singh, Tej V.,Thomas, Sajesh P.,Venugopalan, Paloth. "Friedel-crafts arylation of α-hydroxy ketones: Synthesis of 1,2,2,2-tetraarylethanones". . p. 1226 - 1234. Retrieved 2015/03/04.