2-(Di-t-butylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% t-butylBrettPhos

Base Information

• Chemical Name: 2-(Di-t-butylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% t-butylBrettPhos
• CAS No.: 1160861-53-9
• Molecular Formula: C31H49O2P
• Molecular Weight: 484.703
• Mol file: 1160861-53-9.mol

Synonyms:2-(Di-t-butylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% t-butylBrettPhos;2-(Di-tert-butylphosphino)-2′,4′,6′- triisopropyl-3,6-dimethoxy-1,1′-biphenyl;[3,6-Dimethoxy-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]bis(1,1-dimethylethyl)phosphine;Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxybiphenyl-2-yl)phosphine;2-(Di-t-butylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl;2-(Di-tert-butylphosphino)-2',4',6'-triisopropyl-3,6-diMethoxybiphenyl, 97+%;Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine;2-(Di-tert-butylphosphino)-2',4',6'-triisopropyl-3,6-diMethoxybiphenyl

Chemical Property of 2-(Di-t-butylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% t-butylBrettPhos

Chemical Property:

• Melting Point: 166-170°C
• Boiling Point: 534.9±50.0 °C(Predicted)
• PSA: 32.05000
• LogP: 9.44520

Purity/Quality:

98% ^*data from raw suppliers

tert-ButylBrettPhos ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Di-t-butylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% t-butylBrettPhos

There total 5 articles about 2-(Di-t-butylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% t-butylBrettPhos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

di(tert-butyl)chlorophosphine (13716-10-4) + 2-iodo-2’,4’,6’-triisopropyl-3,6-dimethoxybiphenyl (1070663-76-1) → t-BuBrettPhos (1160861-53-9)

Guidance literature:

di(tert-butyl)chlorophosphine; With magnesium; In tetrahydrofuran; at -10 - 10 ℃; for 2h; Inert atmosphere;

2-iodo-2’,4’,6’-triisopropyl-3,6-dimethoxybiphenyl; With tetrakis(triphenylphosphine)nickel⁽⁰⁾; In tetrahydrofuran; at 80 ℃; for 12h;

Reference yield: 90.0%

di(tert-butyl)chlorophosphine (13716-10-4) + 2-bromo-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl (1402393-56-9) → t-BuBrettPhos (1160861-53-9)

Guidance literature:

di(tert-butyl)chlorophosphine; With magnesium; In tetrahydrofuran; at -10 - 10 ℃; for 2h; Inert atmosphere;

2-bromo-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl; With bis(acetylacetonate)nickel(II); In tetrahydrofuran; at 80 ℃; for 12h;

Reference yield: 18.0%

di(tert-butyl)chlorophosphine (13716-10-4) + 2,4,6-triisopropyl-1-bromobenzene (21524-34-5) + 2-fluoro-1,4-dimethoxybenzene (82830-49-7) → t-BuBrettPhos (1160861-53-9)

Guidance literature:

2,4,6-triisopropyl-1-bromobenzene; With magnesium; ethylene dibromide; In tetrahydrofuran; Inert atmosphere; Reflux;

2-fluoro-1,4-dimethoxybenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

di(tert-butyl)chlorophosphine; With copper(l) chloride; In tetrahydrofuran; hexane; at 20 - 75 ℃; for 48h;

upstream raw materials:

di(tert-butyl)chlorophosphine

2,4,6-triisopropyl-1-bromobenzene

2-fluoro-1,4-dimethoxybenzene

2-iodo-2’,4’,6’-triisopropyl-3,6-dimethoxybiphenyl

Refernces

• 1、 Hoshiya, Naoyuki,Buchwald, Stephen L.. "An improved synthesis of brettphos- and rockphos-type biarylphosphine ligands". experimental part. p. 2031 - 2037. Retrieved 2012/10/08.
• 2、 Fors, Brett P.,Dooleweerdt, Karin,Zeng, Qingle,Buchwald, Stephen L.. "An efficient system for the Pd-catalyzed cross-coupling of amides and aryl chlorides". experimental part. p. 6576 - 6583. Retrieved 2011/02/25.