N-(3-Chloro-2-methylphenyl)acetamide

Base Information

• Chemical Name: N-(3-Chloro-2-methylphenyl)acetamide
• CAS No.: 7463-35-6
• Molecular Formula: C9H10ClNO
• Molecular Weight: 183.637
• Hs Code.: 2924299090
• European Community (EC) Number: 231-254-2
• NSC Number: 404347
• UNII: 9QRW4Y28ZX
• DSSTox Substance ID: DTXSID80225613
• Nikkaji Number: J278.869A
• Wikidata: Q83104657
• Mol file: 7463-35-6.mol

Synonyms:N-(3-Chloro-2-methylphenyl)acetamide;7463-35-6;3-chloro-2-methylacetanilide;Acetamide, N-(3-chloro-2-methylphenyl)-;3'-Chloro-2'-methylacetanilide;3-Chloro-2-methyl-N-acetylaniline;9QRW4Y28ZX;2-Methyl-3-chloroacetanilide;EINECS 231-254-2;NSC-404347;AI3-18017;NSC404347;Acetamide,N-(3-chloro-2-methylphenyl)-;UNII-9QRW4Y28ZX;SCHEMBL476919;3'-Chloro-ortho-acetotoluidide;DTXSID80225613;N-Acetyl-3-chloro-2-methylaniline;STR09834;MFCD00018264;STL497644;AKOS001044970;N-(2-Methyl-3-chlorophenyl)acetamide;NSC 404347;N-(3-Chloro-2-methyl phenyl)acetamide;n-(3-chloro-2-methyl-phenyl)-acetamide;CS-0007911;FT-0615351;Z28292377

Chemical Property of N-(3-Chloro-2-methylphenyl)acetamide

Chemical Property:

• Vapor Pressure: 0.00039mmHg at 25°C
• Melting Point: 155-157°C
• Refractive Index: 1.581
• Boiling Point: 317.2 °C at 760 mmHg
• Flash Point: 145.7 °C
• PSA: 29.10000
• Density: 1.218 g/cm³
• LogP: 2.67980
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 183.0450916
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-2-methyl-N-acetylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=C(C=CC=C1Cl)NC(=O)C

Technology Process of N-(3-Chloro-2-methylphenyl)acetamide

There total 8 articles about N-(3-Chloro-2-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic anhydride (108-24-7) + 3-chloro-2-methylbenzenamine (87-60-5) → N-(3-chloro-2-methylphenyl)acetamide (7463-35-6)

Guidance literature:

In ethanol; at 20 ℃; for 2h;

DOI:10.1021/jm070312d

Reference yield: 72.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + 3-chloro-2-methylbenzenamine (87-60-5) → N-(3-chloro-2-methylphenyl)acetamide (7463-35-6)

Guidance literature:

With 1,2,4-Triazole; 8-quinolinol; copper(II) choride dihydrate; at 150 ℃;

DOI:10.1002/cctc.201800609

Reference yield:

3-chloro-2-methylbenzenamine (87-60-5) → N-(3-chloro-2-methylphenyl)acetamide (7463-35-6)

Guidance literature:

With acetic anhydride; In acetic acid;

upstream raw materials:

3-chloro-2-methyl-aniline; hydrochloride

acetic anhydride

3-chloro-2-methylbenzenamine

6-chloro-2-nitrotoluene

Downstream raw materials:

acetic acid-(3-chloro-2-methyl-6-nitro-anilide)

acetic acid-(3,4-dichloro-2-methyl-anilide)

N-(4-bromo-3-chloro-2-methylphenyl)acetamide

2-(acetylamino)-6-chlorobenzoic acid

Refernces

• 1、 -. "Synthetic method 5- of -4- (-1- I -3-)-(C)-(C)-ethyl-methyl-indol. (by machine translation)". Paragraph 0018; 0020. . Retrieved 2020/02/06.
• 2、 Zeynizadeh, Behzad,Younesi, Reza,Mousavi, Hossein. "Ni2B@Cu2O and Ni2B@CuCl2: two new simple and efficient nanocatalysts for?the green one-pot reductive acetylation of nitroarenes and direct N-acetylation of arylamines using solvent-free mechanochemical grinding". . p. 7331 - 7352. Retrieved 2018/08/25.