N-Cyclopropyl-1-iMidazolecarboxaMide

Base Information

• Chemical Name: N-Cyclopropyl-1-iMidazolecarboxaMide
• CAS No.: 1033090-34-4
• Molecular Formula: C7H9N3O
• Molecular Weight: 151.168
• Hs Code.: 2934999090
• Mol file: 1033090-34-4.mol

Synonyms:N-Cyclopropyl-1-iMidazolecarboxaMide

Chemical Property of N-Cyclopropyl-1-iMidazolecarboxaMide

Chemical Property:

• PSA: 50.41000
• LogP: 0.80760

Purity/Quality:

98%min ^*data from raw suppliers

N-Cyclopropyl-1-imidazolecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Cyclopropyl-1-iMidazolecarboxaMide

There total 2 articles about N-Cyclopropyl-1-iMidazolecarboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

1,1'-carbonyldiimidazole (530-62-1) + Cyclopropylamine (765-30-0) → N-cyclopropyl-1H-imidazole-1-carboxamide (1033090-34-4)

Guidance literature:

In dichloromethane; at 25 ℃;

Reference yield:

1H-imidazole (288-32-4) + isocyanatocyclopropane (4747-72-2) → N-cyclopropyl-1H-imidazole-1-carboxamide (1033090-34-4)

Guidance literature:

In acetonitrile; at 100 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1039/b801634h

Reference yield: 88.6%

4?(4?amino?3?chlorophenoxy)?7?methoxyquinoline?6?carboxamide (417722-93-1) + N-cyclopropyl-1H-imidazole-1-carboxamide (1033090-34-4) → lenvatinib (417716-92-8)

Guidance literature:

4?(4?amino?3?chlorophenoxy)?7?methoxyquinoline?6?carboxamide; N-cyclopropyl-1H-imidazole-1-carboxamide; In N,N-dimethyl-formamide; at 25 ℃;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 85 ℃;

upstream raw materials:

1H-imidazole

isocyanatocyclopropane

1,1'-carbonyldiimidazole

Cyclopropylamine

Downstream raw materials:

2-amino-4-iodo-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

2-amino-4-[2,4-dichloro-6-(2-(pyrazol-1-yl)ethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

lenvatinib

1-(2-chloro-4-hydroxyphenyl)-3-cyclopropyl urea

Refernces

• 1、 -. "AZOLE-SUBSTITUTED PYRIDINE COMPOUND". Paragraph 0659; 0660. . Retrieved 2019/01/08.
• 2、 Zehnder, Luke,Bennett, Michael,Meng, Jerry,Huang, Buwen,Ninkovic, Sacha,Wang, Fen,Braganza, John,Tatlock, John,Jewell, Tanya,Zhou, Joe Zhongxiang,Burke, Ben,Wang, Jeff,Maegley, Karen,Mehta, Pramod P.,Yin, Min-Jean,Gajiwala, Ketan S.,Hickey, Michael J.,Yamazaki, Shinji,Smith, Evan,Kang, Ping,Sistla, Anand,Dovalsantos, Elena,Gehring, Michael R.,Kania, Robert,Wythes, Martin,Kung, Pei-Pei. "Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1h- pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2-difluoropropyl)-5, 7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide". experimental part. p. 3368 - 3385. Retrieved 2011/06/27.