2-(4-Oxo-4-phenylbutyl)-1H-isoindole-1,3(2H)-dione

Base Information

• Chemical Name: 2-(4-Oxo-4-phenylbutyl)-1H-isoindole-1,3(2H)-dione
• CAS No.: 7347-68-4
• Molecular Formula: C18H15NO3
• Molecular Weight: 293.322
• Mol file: 7347-68-4.mol

Synonyms:2-(4-Oxo-4-phenylbutyl)-1H-isoindole-1,3(2H)-dione

Chemical Property of 2-(4-Oxo-4-phenylbutyl)-1H-isoindole-1,3(2H)-dione

Chemical Property:

• PSA: 54.45000
• LogP: 2.88360

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Oxo-4-phenylbutyl)-1H-isoindole-1,3(2H)-dione

There total 8 articles about 2-(4-Oxo-4-phenylbutyl)-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(4-phenylbutyl)-1H-isoindole-1,3(2H)-dione (54981-87-2) → N-(3-benzoylpropyl)phthalimide (7347-68-4)

Guidance literature:

With Oxone; potassium bromide; In nitromethane; at 20 ℃; for 24h;

DOI:10.1021/ol300853z

Reference yield: 77.0%

phthalimide (136918-14-4,85-41-6) + 1-Phenyl-3-buten-1-ol (80735-94-0,936-58-3) → N-(3-benzoylpropyl)phthalimide (7347-68-4)

Guidance literature:

With tetrabutyl-ammonium chloride; oxygen; palladium diacetate; In N,N-dimethyl acetamide; at 80 ℃; for 24h; regioselective reaction; Molecular sieve;

DOI:10.1038/nchem.2904

Reference yield: 74.0%

IZnCu(CN)(CH2)3N(CO)2C6H4 + benzoyl chloride (98-88-4) → N-(3-benzoylpropyl)phthalimide (7347-68-4)

Guidance literature:

at 0 - 5 ℃; for 12h;

DOI:10.15227/orgsyn.070.0195

upstream raw materials:

phthalic anhydride

benzene

phthalimide

4-chloro-1-phenylbutan-1-one

Downstream raw materials:

C₁₇H₁₇N₃

C₁₈H₁₉N₃

Refernces

• 1、 Moriyama, Katsuhiko,Takemura, Misato,Togo, Hideo. "Direct and selective benzylic oxidation of alkylarenes via C-H abstraction using alkali metal bromides". supporting information; experimental part. p. 2414 - 2417. Retrieved 2012/06/18.
• 2、 Yeh, Ming Chang P.,Chen, Huai Gu,Knochel, Paul. "1,2-Addition of a functionalized zinc-copper organometallic [RCu(CN)ZnI] to an α,β-unsaturated aldehyde: (E)-2-(4-hydroxy-6-phenyl-5-hexenyl)-1H-isoindole-1,3(2H)-dione". . p. 195 - 195. Retrieved 2017/05/18.