Kyotorphin

Base Information

• Chemical Name: Kyotorphin
• CAS No.: 70904-56-2
• Molecular Formula: C₁₅H₂₃N₅O₄
• Molecular Weight: 337.379
• UNII: 02N30CW3X0
• DSSTox Substance ID: DTXSID40221136
• Nikkaji Number: J19.925G
• Wikipedia: Kyotorphin
• Wikidata: Q408314
• Metabolomics Workbench ID: 79017
• ChEMBL ID: CHEMBL273521
• Mol file: 70904-56-2.mol

Synonyms:(D-Arg(2))-kyotorphin;D-kyotorphin;kyotorphin;kyotorphin, (L-Tyr-D-Arg)-isomer;kyotorphin, 14C-labeled, (L-Tyr-L-Arg)-isomer;kyotorphin, 3H-labeled, (L-Tyr-D-Arg)-isomer;kyotorphin, 3H-labeled, (L-Tyr-L-Arg)-isomer;L-tyrosyl-D-arginine;L-tyrosyl-L-arginine;Tyr-Arg

Chemical Property of Kyotorphin

Chemical Property:

• PKA: 3.09±0.10(Predicted)
• PSA: 174.55000
• Density: 1.43 g/cm³
• LogP: 1.37680
• Storage Temp.: -20°C
• Solubility.: H2O: soluble20mg/mL, clear
• XLogP3: -4.3
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 9
• Exact Mass: 337.17500423
• Heavy Atom Count: 24
• Complexity: 445

Purity/Quality:

98%Min ^*data from raw suppliers

Kyotorphin acetate salt ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC(C(=O)NC(CCCN=C(N)N)C(=O)O)N)O
• Isomeric SMILES: C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N)O

Technology Process of Kyotorphin

There total 4 articles about Kyotorphin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-arginine (74-79-3,25212-18-4) + L-tyrosine ethyl ester (949-67-7) → kyotorphin (70904-56-2,70904-57-3,92455-38-4) + L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) + H-Tyr-Tyr-Arg-OH

Guidance literature:

With hydrogenchloride; at -26 ℃; for 4h; α-chymotrypsin, pH 10.5;

DOI:10.1016/S0957-4166(00)80359-6

Reference yield:

L-arginine (74-79-3,25212-18-4) + L-tyrosine ethyl ester (949-67-7) → kyotorphin (70904-56-2,70904-57-3,92455-38-4)

Guidance literature:

With hydrogenchloride; at -18 ℃; for 4h; Product distribution; chymotropsin, pH 9.86; var. H-Tyr-OEt and H-Arg-OH conc., pH, and temp.;

DOI:10.1016/S0957-4166(00)80359-6

Reference yield:

→ kyotorphin (70904-56-2,70904-57-3,92455-38-4)

Guidance literature:

upstream raw materials:

L-arginine

L-tyrosine ethyl ester

Refernces

• 1、 -. "Method for protecting guanidino group and restoring the same". . . Retrieved 2008/06/13.