Methenolone

Base Information

• Chemical Name: Methenolone
• CAS No.: 153-00-4
• Molecular Formula: C20H30O2
• Molecular Weight: 302.457
• Hs Code.: 2937290019
• European Community (EC) Number: 205-812-0
• UNII: 9062ZT8Q5C
• DSSTox Substance ID: DTXSID10165179
• Nikkaji Number: J11.393J
• Wikipedia: Metenolone
• Wikidata: Q905078
• NCI Thesaurus Code: C175130
• Metabolomics Workbench ID: 35330
• Mol file: 153-00-4.mol

Synonyms:Metenolone;Methenolone

Chemical Property of Methenolone

Chemical Property:

• Vapor Pressure: 3.26E-09mmHg at 25°C
• Melting Point: 126-129°C(lit.)
• Refractive Index: 1.542
• Boiling Point: 430.381 °C at 760 mmHg
• PKA: 15.08±0.70(Predicted)
• Flash Point: 183.597 °C
• PSA: 37.30000
• Density: 1.084 g/cm³
• LogP: 4.12520
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 302.224580195
• Heavy Atom Count: 22
• Complexity: 536

Purity/Quality:

99.9% ^*data from raw suppliers

Methenolone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=O)CC2C1(C3CCC4(C(C3CC2)CCC4O)C)C
• Isomeric SMILES: CC1=CC(=O)C[C@H]2[C@]1([C@H]3CC[C@]4([C@H]([C@@H]3CC2)CC[C@@H]4O)C)C
• Uses: Methenolone is an anabolic steroid. This is a controlled substance.
• Therapeutic Function: 17β-Hydroxy-1β-methyl-5α-androst-l-ene-3-one acetate

Technology Process of Methenolone

There total 7 articles about Methenolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methenolone enanthate → 17β-hydroxy-1-methyl-5α-androst-1-en-3-one (153-00-4)

Guidance literature:

With Cunninghamella blakesleeana; In methanol; at 26 ℃; for 288h; Microbiological reaction;

DOI:10.1016/j.steroids.2016.04.007

Reference yield:

methenolone enanthate → 17β-hydroxy-1-methyl-5α-androst-1-en-3-one (153-00-4) + 12β,17β-dihydroxy-1-methyl-5α-androstan-1-ene-3-one + 16β,17β-dihydroxy-1-methyl-5α-androstan-1-ene-3-one + 17β-hydroxy-1-methyl-5α-androstan-1-ene-3,16-dione + 15β,17β-dihydroxy-1-methyl-5α-androstan-1-ene-3-one + 1-methyl-5α-androst-1-ene-3,17-dione (1424-01-7)

Guidance literature:

With Aspergillus niger; In methanol; at 26 ℃; for 288h; Microbiological reaction;

DOI:10.1016/j.steroids.2016.04.007

Reference yield:

3-Aethylendioxy-1-methylen-5α-androstanol-(17β) (4360-33-2) → 17β-hydroxy-1-methyl-5α-androst-1-en-3-one (153-00-4)

Guidance literature:

Multistep reaction; (i) Zn-Cu, I₂, CH₂I₂, Et₂O, (ii) aq. H₂SO₄, MeOH;

upstream raw materials:

3-Aethylendioxy-1-methylen-5α-androstanol-(17β)

Downstream raw materials:

17β-acetyloxy-1,4α-dimethyl-2-<(phenylthio)methyl>-5α-androst-1-en-3-one

atamestane

1β-Methyl-4,5α-dihydro-testosteron (17β-Hydroxy-1β-methyl-5α-androstan-3-on)

mesterolone

Refernces