ALPHA-(TRIFLUOROMETHYL)BENZHYDROL

Base Information

• Chemical Name: ALPHA-(TRIFLUOROMETHYL)BENZHYDROL
• CAS No.: 379-18-0
• Molecular Formula: C14H11F3O
• Molecular Weight: 252.236
• Hs Code.: 2906299090
• Mol file: 379-18-0.mol

Synonyms:Benzhydrol,a-(trifluoromethyl)- (7CI,8CI);2,2,2-Trifluoro-1,1-diphenylethanol;NSC 42678;

Chemical Property of ALPHA-(TRIFLUOROMETHYL)BENZHYDROL

Chemical Property:

• Vapor Pressure: 7.97E-05mmHg at 25°C
• Melting Point: 74 °C
• Refractive Index: 1.529
• Boiling Point: 327.8 °C at 760 mmHg
• PKA: 11.10±0.10(Predicted)
• Flash Point: 135.4 °C
• PSA: 20.23000
• Density: 1.26 g/cm³
• LogP: 3.48480

Purity/Quality:

98%min ^*data from raw suppliers

2,2,2-Trifluoro-1,1-diphenylethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of ALPHA-(TRIFLUOROMETHYL)BENZHYDROL

There total 57 articles about ALPHA-(TRIFLUOROMETHYL)BENZHYDROL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzophenone (119-61-9) + trifluoromethan (75-46-7) → 1,1-diphenyl-2,2,2-trifluoroethanol (379-18-0)

Guidance literature:

With phosphazene base-P₄-tert-butyl; In tetrahydrofuran; hexane; at -40 ℃; for 3h; Time; Reagent/catalyst; Inert atmosphere;

DOI:10.1016/j.jfluchem.2013.07.018

Reference yield: 98.0%

benzophenone (119-61-9) + 2,2,2-Trifluoroacetophenone (434-45-7) → 1,1-diphenyl-2,2,2-trifluoroethanol (379-18-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

DOI:10.1016/S0040-4039(02)02718-1

Reference yield: 95.0%

benzophenone (119-61-9) + N-trifluoroacetyl,N-benzyl piperazine (2803-00-1) → 1,1-diphenyl-2,2,2-trifluoroethanol (379-18-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1055/s-2003-36787

upstream raw materials:

ethyl trifluoroacetate,

trifluoroacetic acid-methyl ester

phenyllithium

2,2,2-Trifluoroacetophenone

Downstream raw materials:

diethyl-[3-(2,2,2-trifluoro-1,1-diphenyl-ethoxy)-propyl]-amine

2,2,2-Trifluoro-1,1-diphenylethanol-4-methylbenzenesulfonate

α-(trifluoromethyl)diphenylmethyl cation

(trifluoromethyl)diphenylmethyl bromide

Refernces

• 1、 -. "NOVEL METHOD FOR PRODUCING PERFLUOROALKYLATING AGENTS USING MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL, AND METHOD FOR PRODUCING AROMATIC PERFLUOROALKYL COMPOUND USING THE SAME". Paragraph 0119-0120. . Retrieved 2021/04/09.
• 2、 -. "NOVEL METHOD FOR PRODUCING PERFLUOROALKYLATING AGENTS USING MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL, AND METHOD FOR PRODUCING AROMATIC PERFLUOROALKYL COMPOUNDS USING THE SAME". Paragraph 0119-0120. . Retrieved 2021/04/02.