ethyl 2-morpholin-4-ylpropanoate

Base Information

• Chemical Name: ethyl 2-morpholin-4-ylpropanoate
• CAS No.: 32418-62-5
• Molecular Formula: C9H17NO3
• Molecular Weight: 187.239
• Hs Code.: 2934999090
• Mol file: 32418-62-5.mol

Synonyms:ethyl 2-morpholin-4-ylpropanoate;2-morpholinopropanoic acid ethyl ester;2-morpholinopropionic acid ethyl ester;ethyl 2-morpholinopropanoate

Chemical Property of ethyl 2-morpholin-4-ylpropanoate

Chemical Property:

• Boiling Point: 91-92 °C(Press: 4.5 Torr)
• PKA: 5.14±0.10(Predicted)
• PSA: 38.77000
• Density: 1.056±0.06 g/cm3(Predicted)
• LogP: 0.20810

Purity/Quality:

98%min ^*data from raw suppliers

ethyl2-morpholin-4-ylpropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-morpholin-4-ylpropanoate

There total 4 articles about ethyl 2-morpholin-4-ylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + ethyl diazoalaninate (6111-99-5) → (morpholinyl-4)-2 propanoate d'ethyle (32418-62-5)

Guidance literature:

Cu(homoscorpionate); In 1,2-dichloro-ethane; at 20 ℃;

DOI:10.1039/b207389g

Reference yield: 70.0%

morpholine (110-91-8,99108-56-2) + Ethyl 2-bromopropionate (535-11-5,41978-69-2) → (morpholinyl-4)-2 propanoate d'ethyle (32418-62-5)

Guidance literature:

morpholine; Ethyl 2-bromopropionate; With potassium carbonate; In acetonitrile; at 20 ℃; for 18h; Inert atmosphere;

With sodium hydroxide; In acetonitrile; for 0.166667h;

Reference yield:

2-Morpholin-4-yl-acrylic acid ethyl ester → (morpholinyl-4)-2 propanoate d'ethyle (32418-62-5)

Guidance literature:

With tert-butylmercury chloride; sodium thiosulfate; HSiPh₃; Yield given. Multistep reaction; 1.) DMSO, 1 h, 2.) DMSO;

upstream raw materials:

morpholine

Ethyl 2-bromopropionate

ethyl diazoalaninate

Downstream raw materials:

4-(1-[1,3,4]oxadiazol-2-yl-ethyl)-morpholine

2-Morpholinopropionsaeurehydrazid

Refernces

• 1、 Morilla, M. Esther,Diaz-Requejo, M. Mar,Belderrain, Tomas R.,Nicasio, M. Carmen,Trofimenko, Swiatoslaw,Perez, Pedro J.. "Catalytic insertion of diazo compounds into N-H bonds: The copper alternative". . p. 2998 - 2999. Retrieved 2007/10/03.
• 2、 -. "NEW RENIN-INHIBITORY OLIGOPEPTIDES, THEIR PREPARATION AND THEIR USE". . . Retrieved 2008/06/13.