Methyl 2-iodo-5-Methoxybenzoate

Base Information

• Chemical Name: Methyl 2-iodo-5-Methoxybenzoate
• CAS No.: 857599-37-2
• Molecular Formula: C9H9IO3
• Molecular Weight: 292.073
• Mol file: 857599-37-2.mol

Synonyms:Methyl 2-iodo-5-Methoxybenzoate;2-Iodo-5-Methoxy-benzoic acid Methyl ester

Chemical Property of Methyl 2-iodo-5-Methoxybenzoate

Chemical Property:

• PSA: 35.53000
• LogP: 2.08640
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

95% ^*data from raw suppliers

Methyl2-iodo-5-methoxybenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 2-iodo-5-Methoxybenzoate

There total 6 articles about Methyl 2-iodo-5-Methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-hydroxy-2-iodo-benzoic acid (57772-57-3) + methyl iodide (74-88-4) → methyl 2-iodo-5-methoxybenzoate (857599-37-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; acetone; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.bmcl.2016.01.067

Reference yield: 94.0%

methanol (67-56-1) + 2-iodo-5-methoxybenzoic acid (54413-93-3) → methyl 2-iodo-5-methoxybenzoate (857599-37-2)

Guidance literature:

With sulfuric acid; for 4h; Reflux;

DOI:10.1016/j.cclet.2022.01.070

Reference yield: 90.0%

5-hydroxy-2-iodo-benzoic acid (57772-57-3) + dimethyl sulfate (77-78-1) → methyl 2-iodo-5-methoxybenzoate (857599-37-2)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Inert atmosphere; Reflux;

DOI:10.1002/chem.201403561

upstream raw materials:

diazomethane

5-hydroxy-2-iodo-benzoic acid

dimethyl sulfate

methanol

Downstream raw materials:

C₁₃H₁₅NO₄

methyl 5-methoxy-2-(2-oxo-piperidin-1-yl)-benzoate

2-iodo-5-methoxybenzoic acid

N-(4-ethyl-2-vinylphenyl)-2-iodo-5-methoxybenzamide

Refernces

• 1、 Granchi, Carlotta,Lapillo, Margherita,Glasmacher, Sandra,Bononi, Giulia,Licari, Cristina,Poli, Giulio,El Boustani, Maguie,Caligiuri, Isabella,Rizzolio, Flavio,Gertsch, Jürg,Macchia, Marco,Minutolo, Filippo,Tuccinardi, Tiziano,Chicca, Andrea. "Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor". . p. 1932 - 1958. Retrieved 2019/02/26.
• 2、 Murata, Chihiro,Ogura, Tetsuhiro,Narita, Shuhei,Kondo, Anna P.,Iwasaki, Natsumi,Saito, Tamao,Usuki, Toyonobu. "Synthesis and SAR of 4-methyl-5-pentylbenzene-1,3-diol (MPBD), produced by Dictyostelium discoideum". . p. 1428 - 1433. Retrieved 2016/02/19.