Dicyclomine HCI

Base Information

• Chemical Name: Dicyclomine HCI
• CAS No.: 67-92-5
• Molecular Formula: C19H35 N O2 . Cl H
• Molecular Weight: 345.953
• Hs Code.: 2922199695
• Mol file: 67-92-5.mol

Synonyms:Dicyclomine HCI;AKOS026750112;2-Diethylaminoethyl bicyclohexyl-1-carboxylate HCl

Chemical Property of Dicyclomine HCI

Chemical Property:

• Vapor Pressure: 1.34E-06mmHg at 25°C
• Melting Point: 164-166°C
• Boiling Point: 399.8°C at 760 mmHg
• Flash Point: 116.5°C
• PSA: 29.54000
• LogP: 5.20420
• Storage Temp.: -20°C Freezer
• Solubility.: H2O: 50 mg/mL
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 345.2434571
• Heavy Atom Count: 23
• Complexity: 326

Purity/Quality:

99%, ^*data from raw suppliers

Dicyclomine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [H+].CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2.[Cl-]
• Description: Dicyclomine is an M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM, respectively). It inhibits inositol phosphate accumulation induced by the non-selective acetylcholine agonist carbamoylcholine (carbachol; ) in guinea pig cortex (Ki = 12 nM; pA2 = 7.88). Dicyclomine (10 mg/kg, i.v.) inhibits potassium-induced contraction of ileum, colon, and duodenum in anesthetized rats by 21.85, 30.81, and 37.86%, respectively. Formulations containing dicyclomine have been used to treat functional and irritable bowel syndrome and to relieve muscle spasms in the gastrointestinal tract.
• Uses: Used as a gastrointestinal antispasmodic antacid anticholinergic Dicyclomine Hydrochloride can be used as medication to treat gastric diseases.
• Therapeutic Function: Spasmolytic
• Clinical Use: Dicyclomine Hydrochloride is used for itsspasmolytic effect on various smooth muscle spasms, particularlythose associated with the GI tract. It is also usefulin dysmenorrhea, pylorospasm, and biliary dysfunction.

Technology Process of Dicyclomine HCI

There total 1 articles about Dicyclomine HCI which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ dicyclomine hydrochloride (67-92-5)

Guidance literature:

2-Diethylaminoethyl-1-phenylcyclohexancarboxylathydrochlorid, Rh/Al/Eisessig, Hydrierung;