Technology Process of Nepodin
There total 7 articles about Nepodin which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
boron trichloride;
In
dichloromethane;
for 23h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / H2, conc. HCl / 10percent Pd/C / ethanol
2: pyridine / 24 h / Ambient temperature
3: 74 percent / BF3*Et2O / 1 h / 60 °C
4: 85 percent / BCl3 / CH2Cl2 / 23 h / Ambient temperature
With
pyridine; hydrogenchloride; boron trifluoride diethyl etherate; hydrogen; boron trichloride;
palladium on activated charcoal;
In
ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature
2: 98 percent / H2, conc. HCl / 10percent Pd/C / ethanol
3: pyridine / 24 h / Ambient temperature
4: 74 percent / BF3*Et2O / 1 h / 60 °C
5: 85 percent / BCl3 / CH2Cl2 / 23 h / Ambient temperature
With
pyridine; hydrogenchloride; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; boron trichloride;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
