2-(2,6-Dichlorophenyl)acetohydrazide

Base Information

• Chemical Name: 2-(2,6-Dichlorophenyl)acetohydrazide
• CAS No.: 129564-34-7
• Molecular Formula: C8H8Cl2N2O
• Molecular Weight: 219.07
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID60409131
• Wikidata: Q82214837
• Mol file: 129564-34-7.mol

Synonyms:2-(2,6-dichlorophenyl)acetohydrazide;129564-34-7;Benzeneacetic acid, 2,6-dichloro-, hydrazide;Oprea1_504371;SCHEMBL9527443;DTXSID60409131;MFCD01923147;AKOS000305377;SB86129;VS-03963;CS-0316548;FT-0737635

Chemical Property of 2-(2,6-Dichlorophenyl)acetohydrazide

Chemical Property:

• Vapor Pressure: 2.64E-07mmHg at 25°C
• Boiling Point: 421.3°C at 760 mmHg
• Flash Point: 208.6°C
• PSA: 55.12000
• Density: 1.406g/cm³
• LogP: 2.61700
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 218.0013683
• Heavy Atom Count: 13
• Complexity: 179

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2,6-Dichlorophenyl)acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)Cl)CC(=O)NN)Cl

Technology Process of 2-(2,6-Dichlorophenyl)acetohydrazide

There total 2 articles about 2-(2,6-Dichlorophenyl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(2,6-dichlorophenyl)acetic acid (6575-24-2) → 2-(2,6-dichlorophenyl)acetohydrazide (129564-34-7)

Guidance literature:

With 1,1'-carbonyldiimidazole; hydrazine; In tetrahydrofuran;

DOI:10.1021/ja8019214

Reference yield:

ethyl 2-(2,6-dichlorophenyl)acetate (90793-64-9) → 2-(2,6-dichlorophenyl)acetohydrazide (129564-34-7)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.1002/cjoc.201090120

Reference yield: 100.0%

2-(2,6-dichlorophenyl)acetohydrazide (129564-34-7) + 4-Chlorophenyl isothiocyanate (2131-55-7) → N-(4-chlorophenyl)-2-(2-(2,6-dichlorophenyl)acetyl)hydrazinecarbothioamide (894257-94-4)

Guidance literature:

In ethanol; for 5h; Reflux;

DOI:10.1021/ja8019214

upstream raw materials:

2-(2,6-dichlorophenyl)acetic acid

ethyl 2-(2,6-dichlorophenyl)acetate

Downstream raw materials:

C₁₅H₁₂Cl₃N₃O₂

C₁₅H₁₂Cl₃N₃O₂

N-(2,4-dichlorophenyl)-5-(2,6-dichlorobenzyl)-1,3,4-oxadiazol-2-amine

C₁₆H₁₂Cl₂N₄O₂

Refernces

• 1、 Gao, Yunlong,Zhao, Guilong,Liu, Wei,Wang, Yuli,Xu, Weiren,Wang, Jianwu. "Thiadiazole-based Thioglycosides as Sodium-glucose Co-transporter 2 (SGLT2) Inhibitors". scheme or table. p. 605 - 612. Retrieved 2010/10/19.
• 2、 Zeevaart, Jacob G.,Wang, Ligong,Thakur, Vinay V.,Leung, Cheryl S.,Tirado-Rives, Julian,Bailey, Christopher M.,Domaoal, Robert A.,Anderson, Karen S.,Jorgensen, William L.. "Optimization of azoles as anti-human immunodeficiency virus agents guided by free-energy calculations". supporting information; body text. p. 9492 - 9499. Retrieved 2009/02/03.