6-CHLORO-2H-1-BENZOPYRAN-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 6-CHLORO-2H-1-BENZOPYRAN-3-CARBOXYLIC ACID
• CAS No.: 83823-06-7
• Molecular Formula: C10H7ClO3
• Molecular Weight: 210.617
• Hs Code.: 2916190090
• Mol file: 83823-06-7.mol

Synonyms:6-Chloro-1-benzopyran-3-carboxylicacid;6-Chloro-2H-1-benzopyran-3-carboxylic acid;6-Chloro-2H-benzopyran-3-carboxylic acid;6-Chloro-2H-chromene-3-carboxylicacid;

Chemical Property of 6-CHLORO-2H-1-BENZOPYRAN-3-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 4.96E-06mmHg at 25°C
• Melting Point: 244-246°C
• Boiling Point: 367 °C at 760 mmHg
• Flash Point: 175.7 °C
• PSA: 46.53000
• Density: 1.474 g/cm³
• LogP: 2.20040
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

6-Chloro-2H-chromene-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 22-24/25-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-2H-1-BENZOPYRAN-3-CARBOXYLIC ACID

There total 7 articles about 6-CHLORO-2H-1-BENZOPYRAN-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-chloro-2H-chromene-3-carbonitrile (57543-67-6) → 6-chloro-2H-1-benzopyran-3-carboxylic acid (83823-06-7)

Guidance literature:

With water; sodium hydroxide; for 5h; Reflux;

DOI:10.1002/ardp.201200121

Reference yield: 94.0%

→ 6-chloro-2H-1-benzopyran-3-carboxylic acid (83823-06-7)

Guidance literature:

Reference yield: 87.4%

tert-butyl 3-(5-chloro-2-hydroxyphenyl)-3-hydroxy-2-methylenepropanoate (1215266-96-8) → 6-chloro-2H-1-benzopyran-3-carboxylic acid (83823-06-7)

Guidance literature:

With potassium hydroxide; In water; for 42h; Time; Reflux;

DOI:10.1016/j.tet.2015.04.104

upstream raw materials:

6-chloro-2H-chromene-3-carbonitrile

6-Chloro-2H-chromene-3-carboxylic acid amide

6-chloro-2H-chromene-3-carbaldehyde

5-chlorosalicyclaldehyde

Downstream raw materials:

6-chloro-2H-1-benzopyran-3-carboxylic acid chloride

6-chloro-2H-chromene-3-carboxylic acid [(R)-1-(2-fluoro-4-methanesulfonylamino-5-methylphenyl)ethyl]amide

6-chlorochroman-3-one

N-[3-[2-[bis(1-methylethyl)amino]ethoxy]-4-methoxyphenyl]-3-chloro-benzo[b]thiophene-2-carboxamide

Refernces

• 1、 -. "DUAL AGONISTS OF FXR AND PPARδ AND THEIR USES". Page/Page column 38; 46. . Retrieved 2019/04/16.
• 2、 Mule, Siva Nagi Reddy,Battula, Sailaja Kumari,Velupula, Ganapathi,Guda, Dinneswara Reddy,Bollikolla, Hari Babu. "10-Camphorsulfonic acid ((±)-CSA) catalyzed facile one-pot synthesis of a new class of 2,5-disubstituted 1,3,4-oxadiazoles". . p. 58397 - 58403. Retrieved 2015/02/19.