Cloxacillin sodium

Base Information

• Chemical Name: Cloxacillin sodium
• CAS No.: 7081-44-9
• Molecular Formula: C19H17ClN3NaO5S^.H2O
• Molecular Weight: 475.885
• Hs Code.: 29411099
• Mol file: 7081-44-9.mol

Synonyms:4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, monohydrate, [2S-(2a,5a,6b)]-;3-(o-Chlorophenyl)-5-methyl-4-isoxazolyl penicillin sodium salt monohydrate;Cloxacillin sodium hydrate;Sodium6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylatehydrate;Sodium cloxacillin monohydrate;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-,monosodium salt, monohydrate (8CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, monohydrate, (2S,5R,6R)- (9CI);

Chemical Property of Cloxacillin sodium

Chemical Property:

• Melting Point: 170℃
• Boiling Point: 689.7 °C at 760 mmHg
• Flash Point: 370.9 °C
• PSA: 136.54000
• LogP: 0.99210
• Storage Temp.: 2-8°C
• Solubility.: H2O: soluble50mg/mL
• Water Solubility.: Soluble in water

Purity/Quality:

99% ^*data from raw suppliers

Cloxacillin Sodium Salt Monohydrate >98.0%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-42/43
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Penicillin antibacterial. Targets primarily Gram-positive bacteria, especially -lactamase producing Staphylococci
• Clinical Use: The chlorine atom ortho to the position of attachment of thephenyl ring to the isoxazole ring enhances the activity ofcloxacillin sodium, [3-(o-chlorophenyl)-5-methyl-4-isoxazolyl]penicillin sodium monohydrate (Tegopen), over that ofoxacillin, not by increasing its intrinsic antibacterial activitybut by enhancing its oral absorption, leading to higher plasmalevels. In almost all other respects, it resembles oxacillin.

Technology Process of Cloxacillin sodium

There total 3 articles about Cloxacillin sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-(2'-chlorophenyl)-5-methyl-4-isoxazolyl chloride → cloxacillin sodium salt monohydrate (7081-44-9)

Guidance literature:

Reference yield: 78.8%

2-Ethylhexanoic acid (149-57-5) + 3-(2-chlorophenyl)-5-methyl-4-isoxazolecarboxylic acid (23598-72-3) + sodium 2-ethylhexanoic acid → cloxacillin sodium salt monohydrate (7081-44-9) + 6(3-(o-chlorophenyl)-5-methyl-4-isoxazolylcarboxyamido)penicillanic acid sodium salt

Guidance literature:

With phosphorus pentachloride; triethylamine; In hexane; dichloromethane; water; 4-methyl-2-pentanone;

Reference yield:

→ cloxacillin sodium salt monohydrate (7081-44-9)

Guidance literature:

upstream raw materials:

2-Ethylhexanoic acid

3-(2-chlorophenyl)-5-methyl-4-isoxazolecarboxylic acid

Refernces

• 1、 -. "Process for the activation of carboxylic acids". . . Retrieved 2008/06/13.