2-morpholin-4-ylsulfonylacetic acid

Base Information

• Chemical Name: 2-morpholin-4-ylsulfonylacetic acid
• CAS No.: 78374-13-7
• Molecular Formula: C6H11 N O5 S
• Molecular Weight: 0
• Hs Code.: 2935009090
• Mol file: 78374-13-7.mol

Synonyms:Aceticacid, (4-morpholinylsulfonyl)- (9CI); NSC 329374

Chemical Property of 2-morpholin-4-ylsulfonylacetic acid

Chemical Property:

• Vapor Pressure: 2.01E-08mmHg at 25°C
• Boiling Point: 425.2°C at 760 mmHg
• Flash Point: 211°C
• PSA: 92.29000
• Density: 1.52g/cm³
• LogP: -0.24830

Purity/Quality:

99%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-morpholin-4-ylsulfonylacetic acid

There total 2 articles about 2-morpholin-4-ylsulfonylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(morpholine-4-sulfonyl)-acetic acid ethyl ester (55897-12-6) → (morpholine-4-sulfonyl)-acetic acid (78374-13-7)

Guidance literature:

With potassium hydroxide; In ethanol; Heating;

Reference yield:

(morpholine-4-sulfonyl)-acetic acid methyl ester (952423-92-6) → (morpholine-4-sulfonyl)-acetic acid (78374-13-7)

Guidance literature:

With potassium hydroxide; water; In ethanol; for 16h; Heating / reflux;

Reference yield: 99.0%

[S(S)]-N-[(1R)-1-(3-exo)-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide (952506-23-9) + (morpholine-4-sulfonyl)-acetic acid (78374-13-7) → [S(S)]-N-[(1R)-1-(3-exo)-8-[2-(4-morpholinylsulfonyl)acetyl]-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide (1073923-27-9)

Guidance literature:

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In ethyl acetate; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jo801830x

upstream raw materials:

(morpholine-4-sulfonyl)-acetic acid ethyl ester

(morpholine-4-sulfonyl)-acetic acid methyl ester

Downstream raw materials:

[S(S)]-N-[(1R)-1-(3-exo)-8-[2-(4-morpholinylsulfonyl)acetyl]-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide

Refernces

• 1、 Shridhar, D. R.,Sastry, C. V. Reddy,Lal, K. B.,Marwah, A. K.,Reddi, G. S.,et al.. "Synthesis and Biological Activity of Some New 2--N-arylsulphonamides and 1-sulphonyl Heterocycles". . p. 234 - 237. Retrieved 2007/10/02.