7-bromo-3-cyclopropyl-1,2-benzisoxazole

Base Information

• Chemical Name: 7-bromo-3-cyclopropyl-1,2-benzisoxazole
• CAS No.: 1428881-45-1
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238.08
• Mol file: 1428881-45-1.mol

Synonyms:7-bromo-3-cyclopropyl-1,2-benzisoxazole

Chemical Property of 7-bromo-3-cyclopropyl-1,2-benzisoxazole

Chemical Property:

• Boiling Point: 344.6±22.0 °C(Predicted)
• PSA: 26.03000
• Density: 1.656±0.06 g/cm3(Predicted)
• LogP: 3.46770

Purity/Quality:

7-Bromo-3-cyclopropylbenzo[d]isoxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-bromo-3-cyclopropyl-1,2-benzisoxazole

There total 4 articles about 7-bromo-3-cyclopropyl-1,2-benzisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-(3-bromo-2-fluorophenyl)(cyclopropyl)methanone oxime (1428881-44-0) → 7-bromo-3-cyclopropylbenzo[d]isoxazole (1428881-45-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 70 ℃; for 2h;

Reference yield:

(3-bromo-2-fluorophenyl)(cyclopropyl)methanol (1428881-42-8) → 7-bromo-3-cyclopropylbenzo[d]isoxazole (1428881-45-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2: pyridine; hydroxylamine hydrochloride / 2.5 h / Reflux

3: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 70 °C

With pyridine; hydroxylamine hydrochloride; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

(3-bromo-2-fluorophenyl)(cyclopropyl)methanone (1428881-43-9) → 7-bromo-3-cyclopropylbenzo[d]isoxazole (1428881-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; hydroxylamine hydrochloride / 2.5 h / Reflux

2: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 70 °C

With pyridine; hydroxylamine hydrochloride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

(3-bromo-2-fluorophenyl)(cyclopropyl)methanol

(3-bromo-2-fluorophenyl)(cyclopropyl)methanone

(Z)-(3-bromo-2-fluorophenyl)(cyclopropyl)methanone oxime

3-bromo-2-fluorobenzaldehyde

Refernces