Levomethadone

Base Information Edit

Chemical Name:Levomethadone
CAS No.:125-58-6
Molecular Formula:C21H27 N O
Molecular Weight:309.451
Hs Code.:2922399090
European Community (EC) Number:603-081-6
UNII:6Y75Z4E8NS
DSSTox Substance ID:DTXSID701016376
Nikkaji Number:J56.319F
Wikipedia:Levomethadone
Wikidata:Q6535776
NCI Thesaurus Code:C166969
Pharos Ligand ID:5U1KCPF7PJKZ
Metabolomics Workbench ID:154316
ChEMBL ID:CHEMBL159659
Mol file:125-58-6.mol

Synonyms:Levomethadone;Levothyl;(-)-Methadone;l-Polamivet;(R)-Methadone;(6R)-Methadone;125-58-6;l-Methadone;Levadone;L-Polamidon;D-(-)-Methadone;R-(-)-Methadone;Levomethadone [INN];Levometadona;Levomethadonum;METHADONE, L-;(6R)-6-(dimethylamino)-4,4-diphenylheptan-3-one;UNII-6Y75Z4E8NS;6Y75Z4E8NS;L-6-(Dimethylamino)-4,4-diphenyl-3-heptanone;(R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone;Levomethadone (INN);(-)-(R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone;BRN 3213668;levomethadone HCl;Levometadona [INN-Spanish];Levomethadonum [INN-Latin];(6R)-6-(dimethylamino)-4,4-diphenyl-3-heptanone;3-14-00-00278 (Beilstein Handbook Reference);3-heptanone, 6-(dimethylamino)-4,4-diphenyl-, (6R)-;3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, (R)-;3-HEPTANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, L-;(R)-6-(Dimethylamino)-4,4-diphenyl-3-hetpanone;(-)-(R)-Methadone;3-Hetpanone, 6-(dimethylamino)-4,4-diphenyl-, (R)-;BIDD:PXR0190;SCHEMBL147864;LEVOMETHADONE [WHO-DD];CHEMBL159659;GTPL1605;CHEBI:136003;DTXSID701016376;BDBM50223633;PDSP1_000586;PDSP2_000583;DB13515;D08121;A838934;(6R)-6-(dimethylamino)-4,4-diphenyl-heptan-3-one;(6R)-6-dimethylamino-4,4-di(phenyl)heptan-3-one;Q6535776;HEPTANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, L-;3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, L- (8CI);3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, (6R)- (9CI);3-Hetpanone, 6-(dimethylamino)-4,4-diphenyl-, (R)- (9CI)

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Levomethadone Edit

Chemical Property:

Vapor Pressure:2.2E-07mmHg at 25°C
Melting Point:99°C
Refractive Index:1.5614 (estimate)
Boiling Point:423.7°Cat760mmHg
Flash Point:126.5°C
PSA：20.31000
Density:1.009g/cm³
LogP:4.29200
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:309.209264485
Heavy Atom Count:23
Complexity:346

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
Isomeric SMILES:CCC(=O)C(C[C@@H](C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2

Technology Process of Levomethadone

There total 7 articles about Levomethadone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (6R)-6-(dimethylamino)-4,4-diphenyl-3-heptanone-(+)-N-tosyl glutamate salt

: 125-58-6,297-88-1
levomethadone

Guidance literature:: With ammonium hydroxide; In water; at 25 - 30 ℃; for 1h; pH=8.5 - 9.5;

Reference yield:

: 76-99-3,297-88-1
Methadone

: 5653-80-5,297-88-1
(S)-methadone

: 125-58-6,297-88-1
levomethadone

Guidance literature:: With maltodextrin; In aq. phosphate buffer; at 25 ℃; pH=8; pH-value; Temperature; Reagent/catalyst; Solvent; Resolution of racemate;
DOI:10.1002/chir.23008