ExeMestane Related CoMpound

Base Information

• Chemical Name: ExeMestane Related CoMpound
• CAS No.: 881896-95-3
• Molecular Formula: C₂₁H₂₈O₃
• Molecular Weight: 328.452
• Mol file: 881896-95-3.mol

Synonyms:ExeMestane Related CoMpound;6α-(MethoxyMethyl)androsta-1,4-dien-3,17-dione

Chemical Property of ExeMestane Related CoMpound

Chemical Property:

• PSA: 43.37000
• LogP: 3.73590

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

6α-(Methoxymethyl)androsta-1,4-dien-3,17-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6α-(Methoxymethyl)androsta-1,4-dien-3,17-dione, is a derivative, and a minor product in the synthesis of Exemestane (E957000), and a potential aromatase inhibitor.

Technology Process of ExeMestane Related CoMpound

There total 7 articles about ExeMestane Related CoMpound which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

methanol (67-56-1) + 6β-hydroxymethylandrosta-1,4-diene-3,17-dione (121021-51-0) → (6S,8R,9S,10R,13S,14S)-6-(methoxymethyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione (881896-95-3) + exemestane (107868-30-4)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 24h;

Reference yield: 3.6%

6α-hydroxymethylandrosta-1,4-diene-3,17-dione (933455-74-4) + methyl iodide (74-88-4) → (6S,8R,9S,10R,13S,14S)-6-(methoxymethyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione (881896-95-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃;

Reference yield:

methanol (67-56-1) + 6α-hydroxymethylandrosta-1,4-diene-3,17-dione (933455-74-4) → (6R,8R,9S,10R,13S,14S)-6-(methoxymethyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione (881896-95-3)

Guidance literature:

With sulfuric acid; In water;

upstream raw materials:

methanol

6β-hydroxymethylandrosta-1,4-diene-3,17-dione

Androsta-1,4-diene-3,17-dione

1α,3-dipyrrolidinylandrosta-3,5-dien-17-one

Refernces

• 1、 -. "(S)-6-methyloxaalkyl exemestane compounds and related methods of use". Page/Page column 3. . Retrieved 2008/06/13.