2-(Aminomethyl)-3,5-difluoroaniline

Base Information

• Chemical Name: 2-(Aminomethyl)-3,5-difluoroaniline
• CAS No.: 940054-63-7
• Molecular Formula: C₇H₈F₂N₂
• Molecular Weight: 158.151
• Mol file: 940054-63-7.mol

Synonyms:2-(Aminomethyl)-3,5-difluoroaniline

Chemical Property of 2-(Aminomethyl)-3,5-difluoroaniline

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Aminomethyl)-3,5-difluoroaniline

There total 6 articles about 2-(Aminomethyl)-3,5-difluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-amino-4,6-difluoro-benzamide (893428-66-5) → 2-aminomethyl-3,5-difluorophenylamine (940054-63-7)

Guidance literature:

2-amino-4,6-difluoro-benzamide; With dimethylsulfide borane complex; In tetrahydrofuran; for 8h; Heating / reflux;

With water; In tetrahydrofuran;

Reference yield:

2-amino-4,6-difluorobenzoic acid cyanomethyl ester (940054-62-6) → 2-aminomethyl-3,5-difluorophenylamine (940054-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia / 1,4-dioxane; water / 100 °C

2: dimethylsulfide borane complex / tetrahydrofuran / 8 h / Heating / reflux

With dimethylsulfide borane complex; ammonia; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

2-amino-4,6-difluorobenzoic acid (126674-77-9) → 2-aminomethyl-3,5-difluorophenylamine (940054-63-7)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / acetone / 20 °C

2: ammonia / 1,4-dioxane; water / 100 °C

3: dimethylsulfide borane complex / tetrahydrofuran / 8 h / Heating / reflux

With dimethylsulfide borane complex; ammonia; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; acetone;

upstream raw materials:

2-amino-4,6-difluoro-benzamide

2-amino-4,6-difluorobenzoic acid

2-amino-4,6-difluorobenzoic acid cyanomethyl ester

N-(3,5-difluorophenyl)-2-hydroxyiminoacetamide

Downstream raw materials:

3-(2-amino-4,6-difluorobenzylamino)-pyrrolidine-2,5-dione

Refernces