4-Di-p-tolylamino-benzaldehyde

Base Information

• Chemical Name: 4-Di-p-tolylamino-benzaldehyde
• CAS No.: 42906-19-4
• Molecular Formula: C21H19NO
• Molecular Weight: 301.388
• Hs Code.: 2922399090
• European Community (EC) Number: 255-996-1
• DSSTox Substance ID: DTXSID6068432
• Nikkaji Number: J134.871J
• Wikidata: Q72470231
• Mol file: 42906-19-4.mol

Synonyms:42906-19-4;4-Di-p-tolylamino-benzaldehyde;4-(Di-p-tolyl-amino)-benzaldehyde;4-(Di-p-tolylamino)benzaldehyde;4-Di-p-tolylaminobenzaldehyde;EINECS 255-996-1;4-(4-methyl-N-(4-methylphenyl)anilino)benzaldehyde;Benzaldehyde, 4-[bis(4-methylphenyl)amino]-;Benzaldehyde, 4-(bis(4-methylphenyl)amino)-;4-[bis(p-tolyl)amino]benzaldehyde;4-(Bis(p-tolyl)amino)benzaldehyde;4-Formyl-4',4''-dimethyltriphenylamine;4-[Bis(4-methylphenyl)amino]benzaldehyde;SCHEMBL339173;p-di(p-tolyl)aminobenzaldehyde;4-(dip-tolylamino)benzaldehyde;4-(Di-p-Tlylamino)benzaldehyde;DTXSID6068432;4-(di-p-tolylamino)ben-zaldehyde;4-(di-para-tolylamino)benzaldehyde;BCP32027;4-(di-para-tolylamino) benzaldehyde;MFCD03093257;4- (di-para-tolylamino) benzaldehyde;AKOS015842547;AC-1181;CS-W012124;AS-19123;4-Formyl-4\',4\'\'-dimethyltriphenylamine;A6960;D2737;FT-0630084;4-(N,N-bis(4-methylphenyl)amino)benzaldehyde;4-(N,N-bis(4-methylphenyl)amino) benzaldehyde;Q-102467;4,4'-BIS(4-METHYLPHENYL)- AMINOBENZOALDEHYDE;4,4'-Bis(4-methylphenyl)-aminobenzoaldehyde 4-(DI-P-TOLYLAMINO)BENZALDEHYDE 4-FORMYL-4',4''-DIMETHYLTRIPHENYLAMINE

Chemical Property of 4-Di-p-tolylamino-benzaldehyde

Chemical Property:

• Appearance/Colour: Yellow Powder
• Vapor Pressure: 5.03E-09mmHg at 25°C
• Melting Point: 109 °C
• Refractive Index: 1.649
• Boiling Point: 470.5 °C at 760 mmHg
• PKA: -4.76±0.50(Predicted)
• Flash Point: 182.4 °C
• PSA: 20.31000
• Density: 1.138 g/cm³
• LogP: 5.58570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: almost transparency in hot Acetonitrile
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 301.146664230
• Heavy Atom Count: 23
• Complexity: 336

Purity/Quality:

99% ^*data from raw suppliers

4-(Di-p-tolyl-amino)-benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)N(C2=CC=C(C=C2)C)C3=CC=C(C=C3)C=O

Technology Process of 4-Di-p-tolylamino-benzaldehyde

There total 8 articles about 4-Di-p-tolylamino-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-phenyl-di-p-tolylamine (20440-95-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-[N,N-di(p-tolyl)amino]benzaldehyde (42906-19-4)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; for 0.5h; Cooling with ice;

N-phenyl-di-p-tolylamine; In N,N-dimethyl-formamide; at 70 ℃; for 6h;

DOI:10.1039/c4cc01851f

Reference yield: 95.0%

N-phenyl-di-p-tolylamine (20440-95-3) → 4-[N,N-di(p-tolyl)amino]benzaldehyde (42906-19-4)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide;

Reference yield:

di-p-tolylamine (620-93-9) → 4-[N,N-di(p-tolyl)amino]benzaldehyde (42906-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / copper(l) chloride / toluene

2: trichlorophosphate / N,N-dimethyl-formamide

With KOH; trichlorophosphate; copper(l) chloride; In N,N-dimethyl-formamide; toluene;

upstream raw materials:

N-phenyl-di-p-tolylamine

N,N-dimethyl-formamide

4-tolyl iodide

aniline

Downstream raw materials:

p-di(p-tolyl)aminobenzaldehyde diphenylhydrazone

C₅₂H₄₂N₄

4-(2H-tetrazol-5-yl)phenyl-di(4-tolyl)amine

C₂₈H₂₂BrN₃O

Refernces

• 1、 Lizeng, Liu,Wei, Li,Xianfang, Meng,Dongzhi, Liu,Gongfeng, Xu,Zhengchen, Bai. "Structural, spectral, electrochemistry, thermal properties and theoretical studies on 4-[N, N-di(4-tolyl)amino] benzaldehyde-2-chloro benzoylhydrazone". . p. 201 - 207. Retrieved 2014.
• 2、 Zhang, Zeyuan,Zheng, Yiwen,Sun, Zuobang,Dai, Zhen,Tang, Ziqiang,Ma, Jiangshan,Ma, Chen. "Direct Olefination of Fluorinated Quinoxalines via Cross- Dehydrogenative Coupling Reactions: A New Near-Infrared Probe for Mitochondria". supporting information. p. 2259 - 2268. Retrieved 2017/07/07.
• 3、 Liu, Lizeng,Meng, Xianfang,Li, Wei,Zhou, Xueqin,Bai, Zhengchen,Liu, Dongzhi,Lv, Yunrong,Li, Rui-Hong. "Tuning the photophysical, thermal properties and electronic energy levels in the triphenylamine derivatives by benzoylhydrazone architecture". . p. 32 - 40. Retrieved 2014/05/20.