Benzene, 1-bromo-2-fluoro-5-methyl-4-nitro-

Base Information

• Chemical Name: Benzene, 1-bromo-2-fluoro-5-methyl-4-nitro-
• CAS No.: 948294-26-6
• Molecular Formula: C7H5BrFNO2
• Molecular Weight: 234.025
• Hs Code.: 2904909090
• Mol file: 948294-26-6.mol

Synonyms:Benzene, 1-bromo-2-fluoro-5-methyl-4-nitro-;5-Bromo-4-fluoro-2-nitrotoluene

Chemical Property of Benzene, 1-bromo-2-fluoro-5-methyl-4-nitro-

Chemical Property:

• PSA: 45.82000
• LogP: 3.32800

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Bromo-2-fluoro-5-methyl-4-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 1-bromo-2-fluoro-5-methyl-4-nitro-

There total 3 articles about Benzene, 1-bromo-2-fluoro-5-methyl-4-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-bromo-4-fluorotoluene (452-62-0) → 1-bromo-2-fluoro-5-methyl-4-nitrobenzene (948294-26-6)

Guidance literature:

With sulfuric acid; potassium nitrate; at 5 ℃; for 2h;

Reference yield: 60.0%

4-bromo-5-fluoro-2-methylaniline (52723-82-7) → 1-bromo-2-fluoro-5-methyl-4-nitrobenzene (948294-26-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In cis-1,2-Dichloroethylene; for 2h; Inert atmosphere; Reflux;

Reference yield: 60.0%

4-bromo-5-fluoro-2-methylaniline (52723-82-7) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → 1-bromo-2-fluoro-5-methyl-4-nitrobenzene (948294-26-6)

Guidance literature:

In 1,2-dichloro-ethane; for 2h; Inert atmosphere; Reflux;

upstream raw materials:

3-bromo-4-fluorotoluene

4-bromo-5-fluoro-2-methylaniline

3-chloro-benzenecarboperoxoic acid

Downstream raw materials:

1-bromo-2-fluoro-4-iodo-5-methylbenzene

4-dibromo-5-fluoro-2-methylbenzaldehyde

4-bromo-5-fluoro-2-methylaniline

Refernces

• 1、 -. "NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS". Page/Page column 315; 316. . Retrieved 2017/08/20.
• 2、 Da?browski, Marek,Kubicka, Joanna,Luliński, Sergiusz,Serwatowski, Janusz. "Halogen-lithium exchange between substituted dihalobenzenes and butyllithium: Application to the regioselective synthesis of functionalized bromobenzaldehydes". . p. 6590 - 6595. Retrieved 2007/10/03.