Monoethylglycinexylidide

Base Information

• Chemical Name: Monoethylglycinexylidide
• CAS No.: 7728-40-7
• Molecular Formula: C12H18N2O
• Molecular Weight: 206.288
• Hs Code.: 2924299090
• European Community (EC) Number: 694-788-9
• UNII: D8Q99HC770
• DSSTox Substance ID: DTXSID60228006
• Nikkaji Number: J55.345J
• Wikidata: Q27225703
• Metabolomics Workbench ID: 66926
• ChEMBL ID: CHEMBL1028
• Mol file: 7728-40-7.mol

Synonyms:ethylglycylxylidide;L 86;L-86;MEGX;monoethylglycinexylidide;monoethylglycinexylidide monohydrochloride;monoethylglycinexylidide, 3H,1-(14)C-labeled;Norlidocaine

Chemical Property of Monoethylglycinexylidide

Chemical Property:

• Vapor Pressure: 0.000118mmHg at 25°C
• Melting Point: 242-245°C
• Refractive Index: 1.553
• Boiling Point: 335.6 °C at 760 mmHg
• PKA: pKa 8.04(H2O,t =25±0.2,I=0.01(NaCl)) (Uncertain)
• Flash Point: 127.8 °C
• PSA: 41.13000
• Density: 1.047g/cm³
• LogP: 2.31530
• Storage Temp.: -20°C Freezer
• Solubility.: H2O: soluble10mg/mL, clear
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 206.141913202
• Heavy Atom Count: 15
• Complexity: 196

Purity/Quality:

98%,99%, ^*data from raw suppliers

Nor Lidocaine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNCC(=O)NC1=C(C=CC=C1C)C
• Uses: MEGX has been used in an approach to improve the yield of N-dealkylated lidocaine.

Technology Process of Monoethylglycinexylidide

There total 10 articles about Monoethylglycinexylidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethylamine (75-04-7,85404-22-4) + 2-chloro-N-(2,6-dimethylphenyl)acetamide (1131-01-7) → N-(2,6-dimethylphenyl)-2-ethylaminoacetamide (7728-40-7)

Guidance literature:

With potassium carbonate; In water; acetonitrile; at 20 ℃; for 25h;

Reference yield: 85.0%

lidocaine hydrochloride (73-78-9) → N-(2,6-dimethylphenyl)-2-ethylaminoacetamide (7728-40-7)

Guidance literature:

With glucose dehydrogenase; D-glucose; cytochrome P_450BM3 R₄₇L/Y₅₁F/F₈₁W/F₈₇V/E₂₆₇V/I₄₀₁P mutant; β-nicotinamide adenine dinucleotide phosphate sodium salt; In ethanol; at 25 ℃; for 2h; pH=8.5; Enzymatic reaction;

DOI:10.1002/chem.201502020

Reference yield:

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide (137-58-6) → N-(2,6-dimethylphenyl)-2-ethylaminoacetamide (7728-40-7)

Guidance literature:

With glucose-6-phosphate dehydrogenase; Tris-HCl buffer; D-glucose 6-phosphate; hepatic microsomal suspension; NADP; In water; at 37 ℃; Rate constant; Michaelis constant;

DOI:10.1002/jps.2600730140

upstream raw materials:

ethylamine

2-chloro-N-(2,6-dimethylphenyl)acetamide

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

lidocaine hydrochloride

Downstream raw materials:

C₁₅H₂₂N₂O₃

lidocaine

C₂₂H₃₄N₂O₃S₂

1-ethyl-2-methyl-3-(2,6-dimethylphenyl)imidazolidin-4-one

Refernces

• 1、 Ren, Xinkun,Yorke, Jake A.,Taylor, Emily,Zhang, Ting,Zhou, Weihong,Wong, Luet Lok. "Drug Oxidation by Cytochrome P450BM3: Metabolite Synthesis and Discovering New P450 Reaction Types". . p. 15039 - 15047. Retrieved 2015/10/20.
• 2、 -. "2, 6 XYLIDINE DERIVATIVES FOR THE TREATMENT OF PAIN". Page/Page column 4. . Retrieved 2012/02/03.