4-Methoxytrityl chloride

Base Information

• Chemical Name: 4-Methoxytrityl chloride
• CAS No.: 14470-28-1
• Molecular Formula: C20H17ClO
• Molecular Weight: 308.807
• Hs Code.: 29093090
• European Community (EC) Number: 238-463-8
• NSC Number: 54121
• DSSTox Substance ID: DTXSID90162787
• Nikkaji Number: J150.809A
• Wikidata: Q72486396
• Mol file: 14470-28-1.mol

Synonyms:14470-28-1;4-Methoxytriphenylchloromethane;4-Methoxytrityl chloride;4-Methoxytriphenylmethyl chloride;4-Monomethoxytrityl chloride;(chloro(4-methoxyphenyl)methylene)dibenzene;1-[chloro(diphenyl)methyl]-4-methoxybenzene;4-methoxytritylchloride;p-(Chlorodiphenylmethyl)anisole;Benzene, 1-(chlorodiphenylmethyl)-4-methoxy-;C20H17ClO;p-Anisylchlorodiphenylmethane;MFCD00000814;4-Methoxyriphenylmethylchloride;EINECS 238-463-8;MMTrCl;p-Monomethoxytrityl chloride;1-(chlorodiphenylmethyl)-4-methoxybenzene;NSC54121;MMTr-Cl;p-methoxytrityl chloride;SCHEMBL121800;AMY250;C20-H17-Cl-O;DTXSID90162787;p-methoxyphenylchlorodiphenylmethane;BCP30601;CS-D1424;NSC 54121;NSC-54121;AKOS015851859;4-Methoxytriphenylmethyl chloride, 97%;Diphenyl(p-methoxyphenyl)methyl chloride;AS-15669;SY013719;FT-0618971;FT-0652734;M0790;4-[Chloro(diphenyl)methyl]phenyl methyl ether #;EN300-7370412;J-515683;4-Methoxytrityl chloride pound>>4-Methoxytriphenylchloromethane

Chemical Property of 4-Methoxytrityl chloride

Chemical Property:

• Appearance/Colour: light orange powder
• Vapor Pressure: 4.27E-07mmHg at 25°C
• Melting Point: 122-124 °C(lit.)
• Refractive Index: 1.594
• Boiling Point: 426.8 °C at 760 mmHg
• Flash Point: 208.4 °C
• PSA: 9.23000
• Density: 1.151 g/cm³
• LogP: 5.22590
• Storage Temp.: −20°C
• Sensitive.: Moisture Sensitive
• Solubility.: Soluble in toluene.
• XLogP3: 5.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 308.0967929
• Heavy Atom Count: 22
• Complexity: 305

Purity/Quality:

99% ^*data from raw suppliers

4-Methoxyriphenylmethylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,C
• Hazard Codes: Xi,C
• Statements: 36/37/38-34
• Safety Statements: 26-36-45-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)Cl
• Uses: 4-Methoxytriphenylmethyl chloride is used in the synthesis of N-sulfonyl imines. It is used as selective protecting reagent that is used for primary hydroxyl groups.

Technology Process of 4-Methoxytrityl chloride

There total 12 articles about 4-Methoxytrityl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.1%

p-methoxytrityl alcohol (847-83-6) → mono-4-methoxytrityl chloride (14470-28-1)

Guidance literature:

With acetyl chloride; In benzene; for 1h; Heating;

DOI:10.1021/jo00026a024

Reference yield:

benzophenone (119-61-9) → mono-4-methoxytrityl chloride (14470-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Mg / 1) ether, 2) benzene

2: 89 percent / acetyl chloride / benzene / 1 h / Heating

With magnesium; acetyl chloride; In benzene;

DOI:10.1021/jo00026a024

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) → mono-4-methoxytrityl chloride (14470-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Mg / 1) ether, 2) benzene

2: 89 percent / acetyl chloride / benzene / 1 h / Heating

With magnesium; acetyl chloride; In benzene;

DOI:10.1021/jo00026a024

upstream raw materials:

p-methoxytrityl alcohol

Dichlorodiphenylmethane

methoxybenzene

acetyl chloride

Downstream raw materials:

N-4-methoxytritylaniline

(4-methoxy-trityl)-phenyl-diazene

N-(p-methoxytrityl)-2,2-dimethylsuccinimide

5'-O-monomethoxytritylarabinouridine

Refernces

• 1、 Burton,Cheeseman. "-". . p. 3089,3090. Retrieved 1955.
• 2、 Bent,Dorfman,Bruce. "-". . p. 3250,3256. Retrieved 1932.
• 3、 N?sel, Pascal,Moghimi, Setareh,Hendrich, Christoph,Haupt, Marten,Rudolph, Matthias,Rominger, Frank,Hashmia, A. Stephen K.. "Oxidative gold catalysis meets photochemistry - Synthesis of benzo[a]fluorenones from diynes". supporting information. p. 3755 - 3760. Retrieved 2015/01/09.
• 4、 Singh, Mandeep,Schott, Jason T.,Leon, Martin A.,Granata, Robert T.,Dhah, Harkiran K.,Welles, Jason A.,Boyce, Michelle A.,Oseni-Olalemi, Hafeez S.,Mordaunt, Charles E.,Vargas, Anthony J.,Patel, Nilay V.,Maitra, Santanu. "Design, synthesis and identification of a new class of triarylmethyl amine compounds as inhibitors of apolipoprotein e production". . p. 6252 - 6255. Retrieved 2012/10/29.