Ambroxol hydrochloride

Base Information

• Chemical Name: Ambroxol hydrochloride
• CAS No.: 23828-92-4
• Molecular Formula: C13H19Br2ClN2O
• Molecular Weight: 414.568
• Hs Code.: 29221980
• Mol file: 23828-92-4.mol

Synonyms:Hustless (TN);trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride;(2-amino-3,5-dibromo-phenyl)methyl-(4-hydroxycyclohexyl)azanium;18683-91-5;Ambroxol lozenge;Ambroxol Hcl;Altretamine;Mucoangin;Hustless;Mucolear;

Chemical Property of Ambroxol hydrochloride

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 1.61E-10mmHg at 25°C
• Melting Point: 233-234.5 °C
• Boiling Point: 468.6 °C at 760 mmHg
• Flash Point: 237.2 °C
• PSA: 58.28000
• Density: 1.612 g/cm3
• LogP: 4.96100
• Storage Temp.: 2-8°C
• Solubility.: Sparingly soluble in water, soluble in methanol, practically insoluble in methylene chloride.
• Water Solubility.: Slightly soluble in water (~5 mg/ml) or ethanol (~5 mg/ml).

Purity/Quality:

99.5% up ^*data from raw suppliers

Ambroxol Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ambroxol hydrochloride is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy. Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion. It enhances pulmonary surfactant production and stimulates ciliary activity.
• Indications: Ambroxol Hydrochloride is a bronchosecretolytic drug. It is indicated as “secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe freely and deeply.

Technology Process of Ambroxol hydrochloride

There total 17 articles about Ambroxol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ambroxol (18683-91-5,36557-04-7,107814-37-9) → ambroxol hydrochloride (23828-92-4)

Guidance literature:

With hydrogenchloride; In methanol; for 1h; pH=Ca. 1; Concentration;

Reference yield: 96.26%

trans-4-hydroxycyclohexylamine (27489-62-9) + 3,5-dibromo-2-amino benzaldehyde (50910-55-9) → ambroxol hydrochloride (23828-92-4)

Guidance literature:

trans-4-hydroxycyclohexylamine; 3,5-dibromo-2-amino benzaldehyde; With lithium perchlorate; sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 1.5h;

With hydrogenchloride; In water; acetone; at 20 ℃; for 1h; Solvent;

Reference yield: 95.0%

trans-4-[(2-amino-3,5-dibromobenzylidene)amino]cyclohexanol → ambroxol hydrochloride (23828-92-4)

Guidance literature:

trans-4-[(2-amino-3,5-dibromobenzylidene)amino]cyclohexanol; With methanol; formic acid; 5%-palladium/activated carbon; at 40 ℃; for 5h; Inert atmosphere; Green chemistry;

With hydrogenchloride; In ethanol; water; at 20 ℃; for 2.5h; Reagent/catalyst; Solvent; Green chemistry;

upstream raw materials:

o-toluidine

ambroxol

3,5-dibromo-2-nitro-benzaldehyde

2-nitro-benzaldehyde

Downstream raw materials:

4-(6,8-dibromo-3,4-dihydroquinazolin-3-yl)cyclohexanol

4-(6,8-dibromo-1,4-dihydroquinazolin-3(2H)-yl)-cyclohexanol hydrochloride

ambroxol

Refernces

• 1、 -. "Synthetic method of ambroxol hydrochloride". . . Retrieved 2021/02/10.
• 2、 -. "Preparation method of ambroxol hydrochloride". . . Retrieved 2020/05/14.