2-(4-methylphenoxy)pyridine

Base Information

• Chemical Name: 2-(4-methylphenoxy)pyridine
• CAS No.: 4783-71-5
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.225
• Mol file: 4783-71-5.mol

Synonyms:2-(4-methylphenoxy)pyridine

Chemical Property of 2-(4-methylphenoxy)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methylphenoxy)pyridine

There total 11 articles about 2-(4-methylphenoxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-bromo-pyridine (109-04-6) + 4-tolyl iodide (624-31-7) → 2-(4-methylphenoxy)pyridine (4783-71-5)

Guidance literature:

With copper(l) iodide; cesium hydroxide; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; In dimethyl sulfoxide; at 130 ℃; for 30h; chemoselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201001373

Reference yield: 91.0%

2-bromo-pyridine (109-04-6) + p-cresol (106-44-5) → 2-(4-methylphenoxy)pyridine (4783-71-5)

Guidance literature:

With 2-Picolinic acid; potassium phosphate; copper(l) iodide; In dimethyl sulfoxide; at 100 ℃; for 24h;

DOI:10.1021/acs.joc.8b02104

Reference yield: 85.0%

2-iodopyridine (5029-67-4) + p-cresol (106-44-5) → 2-(4-methylphenoxy)pyridine (4783-71-5)

Guidance literature:

With copper; caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 18h;

DOI:10.1021/om100494p

upstream raw materials:

2-bromo-pyridine

p-cresol

di-2-pyridyl sulfide

2-chloropyridine

Downstream raw materials:

pentyl 5-methyl-2-(pyridin-2-yloxy)benzoate

2-(p-tolyl)naphthalene

Refernces

• 1、 Jia, Chunqi,Wang, Shichong,Lv, Xulu,Li, Gang,Zhong, Lei,Zou, Lei,Cui, Xiuling. "Ruthenium-Catalyzed meta-CAr–H Bond Difluoroalkylation of 2-Phenoxypyridines". supporting information. p. 1992 - 1995. Retrieved 2020/03/23.
• 2、 Abe, Yusuke,Hanazawa, Natsumi,Katagiri, Kotone,Kuriyama, Masami,Ono, Shimpei,Onomura, Osamu,Yamamoto, Kosuke. "N - And O -arylation of pyridin-2-ones with diaryliodonium salts: Base-dependent orthogonal selectivity under metal-free conditions". . p. 8295 - 8300. Retrieved 2020/09/09.