S-nitrosoglutathione(1-)

Base Information

• Chemical Name: S-nitrosoglutathione(1-)
• CAS No.: 57564-91-7
• Molecular Formula: C10H16N4O7S
• Molecular Weight: 336.326
• Hs Code.: 2930909090
• European Community (EC) Number: 637-341-5
• Wikipedia: S-Nitrosoglutathione
• Mol file: 57564-91-7.mol

Synonyms:S-Nitroso-GSH;S-Nitrosoglutathione

Chemical Property of S-nitrosoglutathione(1-)

Chemical Property:

• Appearance/Colour: pink powder
• Melting Point: >170°C (dec.)
• Refractive Index: 1.6000 (estimate)
• PKA: 2.21±0.10(Predicted)
• PSA: 213.55000
• Density: 1.68 g/cm³
• LogP: -0.23920
• Storage Temp.: −20°C
• Solubility.: DMSO (Slightly), Water (Slightly)
• XLogP3: -3.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 8
• Exact Mass: 335.06614500
• Heavy Atom Count: 22
• Complexity: 434

Purity/Quality:

98%, ^*data from raw suppliers

SNOG ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CC(=O)NC(CSN=O)C(=O)NCC(=O)[O-])C(C(=O)[O-])[NH3+]
• Isomeric SMILES: C(CC(=O)N[C@@H](CSN=O)C(=O)NCC(=O)[O-])[C@@H](C(=O)[O-])[NH3+]
• Description: S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.
• Uses: A carrier of nitric oxide, relaxing smooth muscle and inhibiting platelet activation S-Nitrosoglutathione (GSNO) has been used:as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD).as a standard in spectrophotometric and high-performance liquid chromatography (HPLC) assay.

Technology Process of S-nitrosoglutathione(1-)

There total 1 articles about S-nitrosoglutathione(1-) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

GLUTATHIONE (70-18-8) + S-nitroso-N-acetyl-DL-penicillamine (67776-06-1,81739-40-4) → NAP (59-53-0) + S-Nitrosoglutathione (57564-91-7)

Guidance literature:

With phosphate buffer; ethylenediaminetetraacetic acid; for 0.0833333h; pH=7.4; Further Variations:; Temperatures; Equilibrium constant;

DOI:10.1016/S0960-894X(00)00688-0

Reference yield: 100.0%

2-amino-4-mercaptobutyric acid (454-29-5) + S-Nitrosoglutathione (57564-91-7) → S-nitroso-homocysteine (187878-81-5)

Guidance literature:

With sodium perchlorate; at 25 ℃; pH=7.4; aq. phosphate buffer;

DOI:10.1021/jp103679v

Reference yield: 77.0%

C22H22NOPS (1432617-49-6) + S-Nitrosoglutathione (57564-91-7) → C32H38N5O7PS2

Guidance literature:

In water; dimethyl sulfoxide; at 20 ℃; for 0.5h; Darkness;

DOI:10.1021/ja401565w

upstream raw materials:

GLUTATHIONE

S-nitroso-N-acetyl-DL-penicillamine

Downstream raw materials:

S-Phenylsulphonylglutathione

Oxidized glutathione

GLUTATHIONE

S-nitroso-N-acetyl-DL-penicillamine

Refernces