2,3,6-Triaminopyridine

Base Information

• Chemical Name: 2,3,6-Triaminopyridine
• CAS No.: 4318-79-0
• Molecular Formula: C5H8N4
• Molecular Weight: 124.145
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40195767
• Nikkaji Number: J51.346F
• Wikidata: Q83068823
• Mol file: 4318-79-0.mol

Synonyms:2,3,6-pyridinetriamine;2,3,6-triaminopyridine

Chemical Property of 2,3,6-Triaminopyridine

Chemical Property:

• Vapor Pressure: 2.22E-06mmHg at 25°C
• Refractive Index: 1.766
• Boiling Point: 392.9 °C at 760 mmHg
• PKA: 6.05±0.50(Predicted)
• Flash Point: 219.9 °C
• PSA: 90.95000
• Density: 1.387 g/cm³
• LogP: 1.57180
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 124.074896272
• Heavy Atom Count: 9
• Complexity: 95

Purity/Quality:

98%Min ^*data from raw suppliers

PYRIDINE-2,3,6-TRIAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=NC(=C1N)N)N

Technology Process of 2,3,6-Triaminopyridine

There total 1 articles about 2,3,6-Triaminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,6-diamino-3-nitro-pyridine (3346-63-2) → 2,3,6-triaminopyridine (4318-79-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h;

Reference yield: 58.0%

2,3,6-triaminopyridine (4318-79-0) + 1,3-bis(4-nitrophenyl)prop-2-en-1-one (25870-67-1,102692-42-2,102692-57-9) → 2,4-Bis-(4-nitro-phenyl)-4,5-dihydro-3H-pyrido[3,4-b][1,4]diazepin-7-ylamine

Guidance literature:

With acetic acid; In ethanol; for 4h; Heating;

DOI:10.1002/jhet.5570340528

Reference yield: 45.0%

2,3,6-triaminopyridine (4318-79-0) + 3-(4-bromophenyl)-1-(4-nitrophenyl)prop-2-en-1-one (13909-51-8) → 4-(4-Bromo-phenyl)-2-(4-nitro-phenyl)-4,5-dihydro-3H-pyrido[3,4-b][1,4]diazepin-7-ylamine

Guidance literature:

With acetic acid; In ethanol; for 4h; Heating;

DOI:10.1002/jhet.5570340528

upstream raw materials:

2,6-diamino-3-nitro-pyridine

Downstream raw materials:

3-phenyl-pyrido[2,3-b]pyrazin-6-ylamine

2-(4-fluorophenyl)-5-aminoimidazo[4,5-b]pyridine

2-(4-Nitro-phenyl)-1H-imidazo[4,5-b]pyridin-5-ylamine

Refernces

• 1、 -. "NOVEL PYRIDOPYRAZINES AND USE THEREOF AS KINASE INHIBITORS". Page/Page column 16; 28-29. . Retrieved 2010/02/09.