(R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine

Base Information

• Chemical Name: (R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine
• CAS No.: 103596-36-7
• Molecular Formula: C₁₂H₁₄FN
• Molecular Weight: 191.248
• Mol file: 103596-36-7.mol

Synonyms:(R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine

Chemical Property of (R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine

There total 5 articles about (R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-fluoroamphetamine (459-02-9) + propargyl bromide (106-96-7) → (R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine (103596-36-7)

Guidance literature:

With potassium carbonate; In water; toluene; acetonitrile;

DOI:10.1021/jm00169a034

Reference yield: 55.0%

4-fluorophenyl acetone (459-03-0) + Propargylamine (2450-71-7) → (R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine (103596-36-7)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201705848

Reference yield:

1-(4-fluorophenyl)-2-nitropropene (134538-46-8,775-31-5) → (R,S)-(+/-)-α-methyl-β-(4-fluorophenyl)-N-propynylethylamine (103596-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / LiAlH₄ / tetrahydrofuran / 4 h / Ambient temperature

2: 62 percent / K₂CO₃ / acetonitrile; toluene; H₂O

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; water; toluene; acetonitrile;

DOI:10.1021/jm00169a034

upstream raw materials:

4-fluoroamphetamine

propargyl bromide

1-(4-fluorophenyl)-2-nitropropene

4-fluorobenzaldehyde

Downstream raw materials:

N-methyl-N-(1-(4-fluoro-phenyl)-2-propyl)-2-propynylamine

Refernces

• 1、 Plenevaux,Dewey,Fowler,Guillaume,Wolf. "Synthesis of (R)-(-)- and (S)-(+)-4-fluorodeprenyl and (R)-(-)- and (S)-(+)-[N-11C-methyl]-4-fluorodeprenyl and positron emission tomography studies in baboon brain". . p. 2015 - 2019. Retrieved 2007/10/02.