1-[(4-nitrophenyl)sulfonyl]aziridine

Base Information

• Chemical Name: 1-[(4-nitrophenyl)sulfonyl]aziridine
• CAS No.: 43090-97-7
• Molecular Formula: C8H8N2O4S
• Molecular Weight: 228.229
• Mol file: 43090-97-7.mol

Synonyms:1-(4-Nitrophenyl)sulfonylaziridine;1-((4-Nitrophenyl)sulfonyl)aziridine;

Chemical Property of 1-[(4-nitrophenyl)sulfonyl]aziridine

Chemical Property:

• Vapor Pressure: 8.9E-07mmHg at 25°C
• Refractive Index: 1.656
• Boiling Point: 405.2 °C at 760 mmHg
• Flash Point: 198.9 °C
• PSA: 91.35000
• Density: 1.591 g/cm³
• LogP: 2.14100

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[(4-nitrophenyl)sulfonyl]aziridine

There total 9 articles about 1-[(4-nitrophenyl)sulfonyl]aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-((4-nitrophenyl)sulfonamido)ethyl ethanesulfonate → 1-(4-nitro-benzenesulfonyl)-aziridine (43090-97-7)

Guidance literature:

With potassium hydroxide; In water; benzene; for 1h; Inert atmosphere;

DOI:10.1002/anie.202015339

Reference yield: 82.0%

N-(2-chloro-ethyl)-4-nitro-benzenesulfonamide (43090-96-6) → 1-(4-nitro-benzenesulfonyl)-aziridine (43090-97-7)

Guidance literature:

With potassium hydroxide; In water; toluene; at 20 ℃;

Reference yield:

2-(4-nitrophenylsulfonylamino)ethyl methanesulfonate (1370451-29-8) → 1-(4-nitro-benzenesulfonyl)-aziridine (43090-97-7)

Guidance literature:

With potassium hydroxide; In water; toluene; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2012.02.071

upstream raw materials:

ethyleneimine

4-Nitrobenzenesulfonyl chloride

N-(2-hydroxyethyl)-4-nitrobenzenesulfonamide

C₁₄H₁₃N₃O₉S₂

Downstream raw materials:

N-{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecan-1-yl]ethyl}-N-(tert-butoxycarbonyl)-4-nitrobenzenesulfonamide

N-[2-(N₄,N₇,N₁₀-tri-tert-butoxycarbonyl-1,4,7,10-tetraazacyclododecan-1-yl)ethyl]-4-nitrobenzenesulfonamide

1-[2-(4-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane

Refernces

• 1、 Qian, Guangyin,Bai, Miao,Gao, Shijun,Chen, Han,Zhou, Siwei,Cheng, Hong-Gang,Yan, Wei,Zhou, Qianghui. "Modular One-Step Three-Component Synthesis of Tetrahydroisoquinolines Using a Catellani Strategy". supporting information. p. 10980 - 10984. Retrieved 2018/07/30.
• 2、 -. "NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK". . . Retrieved 2017/04/04.