Technology Process of methyl 5-cyano-6-(4-fluorophenyl)-2-hydroxy-4-phenyl-3,4-dihydro-2H-pyran-2-carboxylate
There total 4 articles about methyl 5-cyano-6-(4-fluorophenyl)-2-hydroxy-4-phenyl-3,4-dihydro-2H-pyran-2-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
C36H50N4O4; 4-(1,1-dimethylethyl)benzoic acid;
In
tert-butyl methyl ether;
at -30 ℃;
for 72h;
Molecular sieve;
Inert atmosphere;
DOI:10.1021/ol400894j
- Guidance literature:
-
Multi-step reaction with 3 steps
1: boron trifluoride diethyl etherate / dichloromethane / 3 h / -78 - 0 °C / Inert atmosphere
2: silica gel / benzene / 24 h / Reflux
3: C36H50N4O4; 4-(1,1-dimethylethyl)benzoic acid / tert-butyl methyl ether / 72 h / -30 °C / Molecular sieve; Inert atmosphere
With
boron trifluoride diethyl etherate; C36H50N4O4; silica gel; 4-(1,1-dimethylethyl)benzoic acid;
In
dichloromethane; tert-butyl methyl ether; benzene;
3: |Michael Addition;
DOI:10.1021/ol400894j
- Guidance literature:
-
Multi-step reaction with 2 steps
1: silica gel / benzene / 24 h / Reflux
2: C36H50N4O4; 4-(1,1-dimethylethyl)benzoic acid / tert-butyl methyl ether / 72 h / -30 °C / Molecular sieve; Inert atmosphere
With
C36H50N4O4; silica gel; 4-(1,1-dimethylethyl)benzoic acid;
In
tert-butyl methyl ether; benzene;
2: |Michael Addition;
DOI:10.1021/ol400894j
