Antapentan

Base Information

• Chemical Name: Antapentan
• CAS No.: 634-03-7
• Deprecated CAS: 16311-86-7,711-71-7
• Molecular Formula: C12H17 N O
• Molecular Weight: 191.273
• European Community (EC) Number: 211-204-6
• UNII: AB2794W8KV
• DSSTox Substance ID: DTXSID1023447
• Nikkaji Number: J6.905A
• Wikipedia: Phendimetrazine
• Wikidata: Q1649219
• NCI Thesaurus Code: C61887
• RXCUI: 33272
• Pharos Ligand ID: MSBAHZYNRG53
• Metabolomics Workbench ID: 67709
• ChEMBL ID: CHEMBL1615439
• Mol file: 634-03-7.mol

Synonyms:Adipost;Bontril;Di-Ap-Trol;Dyrexan;Hyrex;Melfiat;Obezine;phendimetrazine;phendimetrazine hydrochloride;phendimetrazine hydrochloride, (2S-trans)-isomer;phendimetrazine tartrate;phendimetrazine tartrate, (2S-trans(R-(R*,R*)))-isomer;phendimetrazine tartrate, (R-(R*,R*))-isomer;phendimetrazine, (2R-cis)-isomer;phendimetrazine, (2S-trans)-isomer;phendimetrazine, trans(+-)-isomer;Prelu-2;Trimstat;Wehless;Weightrol;X-Trozine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Antapentan

Chemical Property:

• Vapor Pressure: 0.00514mmHg at 25°C
• Boiling Point: 275.3°Cat760mmHg
• PKA: 7.51±0.40(Predicted)
• Flash Point: 80.9°C
• PSA: 12.47000
• Density: 0.992g/cm³
• LogP: 2.01610
• Storage Temp.: Controlled Substance, -20°C Freezer
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 191.131014166
• Heavy Atom Count: 14
• Complexity: 177

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C(OCCN1C)C2=CC=CC=C2
• Isomeric SMILES: C[C@H]1[C@@H](OCCN1C)C2=CC=CC=C2
• Recent ClinicalTrials: Reinforcing Effects of Cocaine During Phendimetrazine Maintenance
• Uses: An Amphetamine derivative. Controlled substance (stimulant).

Technology Process of Antapentan

There total 10 articles about Antapentan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + trans-Phenmetrazine (134-49-6,1618-50-4,13580-23-9,57919-12-7,63971-50-6,84025-82-1,21288-73-3) → trans-Phendimetrazine (634-03-7,711-72-8,21784-30-5,27032-15-1,29493-75-2,38323-36-3)

Guidance literature:

With formic acid; In water; at 25 ℃; Reflux;

DOI:10.1021/ja104168q

Reference yield:

oxirane (75-21-8,99932-75-9) + ephedrine (299-42-3,7009-81-6,90-83-5,6912-63-6) → phendimetrazine (634-03-7)

Guidance literature:

anschliessend mit konz. H₂SO₄ behandeln;

Reference yield:

ephedrine (299-42-3,7009-81-6,90-83-5,6912-63-6) + 2-chloro-ethanol (107-07-3) → phendimetrazine (634-03-7)

Guidance literature:

anschliessend mit konz. H₂SO₄ behandeln;

upstream raw materials:

oxirane

ephedrine

2-chloro-ethanol

(1RS,2SR)-2-[(2-hydroxy-ethyl)-methyl-amino]-1-phenyl-propan-1-ol

Downstream raw materials:

trans-Phenmetrazine

trans-2-Phenyl-3,4-dimethyl-5-morpholinone

4-formyl-3-methyl-2-phenylmorpholine

Refernces

• 1、 Yordanova,Dantchev,Shvedov,Karanov. "Synthesis of 3,4-dialkyl-2-phenylmorpholines". . p. 41 - 42. Retrieved 2007/10/02.