Paricalcitol

Base Information Edit

Chemical Name:Paricalcitol
CAS No.:131918-61-1
Molecular Formula:C₂₇H₄₄O₃
Molecular Weight:416.645
Hs Code.:2936299055
Mol file:131918-61-1.mol

Synonyms:19-Nor-9,10-secoergosta-5,7,22-triene-1,3,25-triol,(1a,3b,7E,22E)- (9CI);19-Nor-1,25-dihydroxyvitamin D2;1a,25-Dihydroxy-19-nor-vitamin D2;1,3-Cyclohexanediol,5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-,(1R,3R,5Z)-;Zemplar;

Suppliers and Price of Paricalcitol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Paricalcitol
1mg
$ 452.00

TRC
Paricalcitol
1mg
$ 85.00

Tocris
Paricalcitol ≥98%(HPLC)
1
$ 201.00

Sigma-Aldrich
Paricalcitol
3ml
$ 685.00

Sigma-Aldrich
Paricalcitol
10mg
$ 3560.00

Medical Isotopes, Inc.
Paricalcitol
1 mg
$ 1500.00

DC Chemicals
Paricalcitol >98%
50 mg
$ 2000.00

Crysdot
Paricalcitol 98+%
5mg
$ 462.00

Crysdot
Paricalcitol 98+%
10mg
$ 770.00

Chemtos
ParicalcitolLabeledd6
10 mg
$ 3500.00

Total 147 raw suppliers

Chemical Property of Paricalcitol Edit

Chemical Property:

Vapor Pressure:4.13E-15mmHg at 25°C
Refractive Index:1.609
Boiling Point:564.8 °C at 760 mmHg
PKA:14.34±0.40(Predicted)
Flash Point:238.4 °C
PSA：60.69000
Density:1.121 g/cm³
LogP:5.56060

Purity/Quality:

99%min ^*data from raw suppliers

Paricalcitol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well. Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.
Uses Synthetic analog of vitamin D. Antihyperparathyroid. Antihyperparathyriod 1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.
Clinical Use Vitamin D analogue: Treatment and prevention of secondary hyperparathyroidism associated with chronic renal failure
Drug interactions Potentially hazardous interactions with other drugs None known

Technology Process of Paricalcitol

There total 72 articles about Paricalcitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%