Technology Process of (S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester
There total 1 articles about (S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / toluene / Reflux; Dean-Stark
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -50 - -40 °C
2.2: 0.5 h / -55 - -45 °C
3.1: potassium hydrogencarbonate / methanol; water / 10 - 50 °C
4.1: potassium tert-butylate / tetrahydrofuran / 1 h / 10 - 60 °C
4.2: 10 - 60 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 50 - 60 °C
6.1: palladium 10% on activated carbon; ammonium formate / methanol; water / 10 - 50 °C / Inert atmosphere
7.1: dichloromethane / 20 - 45 °C
7.2: 20 °C
With
lithium aluminium tetrahydride; palladium 10% on activated carbon; potassium tert-butylate; ammonium formate; potassium hydrogencarbonate; toluene-4-sulfonic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
- Guidance literature:
-
With
Jones reagent;
In
acetone;
at 0 - 37 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C / Inert atmosphere; Cooling with ice
2: hydrazine hydrate / ethanol / 20 °C
3: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C
With
hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; ethanol; toluene; acetonitrile;