H-ASP-LEU-OH

Base Information

• Chemical Name: H-ASP-LEU-OH
• CAS No.: 3062-14-4
• Molecular Formula: C10H18N2O5
• Molecular Weight: 246.26
• Hs Code.: 2924199090
• Mol file: 3062-14-4.mol

Synonyms:H-ASP-LEU-OH;L-ASPARTIC ACID-L-LEUCINE

Chemical Property of H-ASP-LEU-OH

Chemical Property:

• Vapor Pressure: 1.53E-12mmHg at 25°C
• Boiling Point: 527.6°Cat760mmHg
• PKA: 2.99±0.10(Predicted)
• Flash Point: 272.9°C
• PSA: 129.72000
• Density: 1.272g/cm³
• LogP: 0.49510
• Storage Temp.: -15°C
• Solubility.: Chloroform (Very Slightly, Heated, Sonicated), Water (Slightly)

Purity/Quality:

99%+, ^*data from raw suppliers

(S)-2-((S)-2-Amino-3-carboxypropanamido)-4-methylpentanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-ASP-LEU-OH

There total 4 articles about H-ASP-LEU-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(O-benzyl-N-benzyloxycarbonyl-L-α-aspartyl)-L-leucine benzyl ester (119278-21-6) → Asp-Leu (3062-14-4)

Guidance literature:

With palladium; acetic acid;

Reference yield:

L-Leucine benzyl ester (1738-69-8) → Asp-Leu (3062-14-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide

2: catalytic hydrogenation

With dicyclohexyl-carbodiimide;

Reference yield:

L-leucine benzyl ester hydrochloride (2462-35-3) → Asp-Leu (3062-14-4)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorocarbonic acid butyl ester

2: palladium; aqueous ethanol acetic acid

With palladium; acetic acid; carbonochloridic acid, butyl ester;

upstream raw materials:

N-(O-benzyl-N-benzyloxycarbonyl-L-α-aspartyl)-L-leucine benzyl ester

L-Leucine benzyl ester

L-leucine benzyl ester hydrochloride

Refernces

• 1、 Ohyama, Satoshi,Ishibashi, Norio,Tamura, Masahiro,Nishizaki, Hiroshi,Okai, Hideo. "Synthesis of Bitter Peptides Composed of Aspartic Acid and Glutamic acid". . p. 871 - 872. Retrieved 2007/10/02.