2-Bromophenylhydrazine hydrochloride

Base Information

• Chemical Name: 2-Bromophenylhydrazine hydrochloride
• CAS No.: 50709-33-6
• Molecular Formula: C6H7BrN2^.HCl
• Molecular Weight: 223.5
• Hs Code.: 29280000
• European Community (EC) Number: 256-728-6
• DSSTox Substance ID: DTXSID30198762
• Mol file: 50709-33-6.mol

Synonyms:2-Bromophenylhydrazine hydrochloride;50709-33-6;2-Bromophenylhydrazine HCl;(2-bromophenyl)hydrazine hydrochloride;2-Bromophenylhydrazine, HCl;Hydrazine, (2-bromophenyl)-, monohydrochloride;EINECS 256-728-6;(2-bromophenyl)hydrazine;hydrochloride;1-(2-BROMOPHENYL)HYDRAZINE HYDROCHLORIDE;SCHEMBL597675;DTXSID30198762;PHCYUJRYSFMJMG-UHFFFAOYSA-N;BCP31965;o-bromo-phenylhydrazine hydrochloride;2-bromophenyl hydrazine hydrochloride;MFCD00012926;AKOS005255198;AC-6007;CS-W013082;SB80162;2-Bromophenylhydrazine hydrochloride, 98%;AM20061114;B2147;FT-0611598;EN300-25695;W-105933;Z216309278

Chemical Property of 2-Bromophenylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.00502mmHg at 25°C
• Melting Point: 189 °C (dec.)(lit.)
• Boiling Point: 275.7 °C at 760 mmHg
• Flash Point: 120.5 °C
• PSA: 38.05000
• LogP: 3.31000
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Hygroscopic
• Solubility.: slightly sol. in Methanol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 221.95594
• Heavy Atom Count: 10
• Complexity: 87.1

Purity/Quality:

99% ^*data from raw suppliers

2-Bromophenylhydrazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C, Xn
• Hazard Codes: C,Xn
• Statements: 34-20/21-31-20
• Safety Statements: 26-27-36/37/39-45-23

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)NN)Br.Cl
• Uses: 2-Bromophenylhydrazine hydrochloride was used to prepare 6-(3-bromophenylhydrazono)-7,8,9,11-tetrahydropyrido[2,1-b]quinazoline-11-one.

Technology Process of 2-Bromophenylhydrazine hydrochloride

There total 3 articles about 2-Bromophenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%

→ 2-bromophenylhydrazine hydrochloride hydrate + 2-bromophenylhydrazine hydrochloride (50709-33-6)

Guidance literature:

Reference yield:

2-bromoaniline (615-36-1) → 2-bromophenylhydrazine hydrochloride (50709-33-6)

Guidance literature:

2-bromoaniline; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃;

With hydrogenchloride; tin(ll) chloride; In water; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2010.07.038

Reference yield:

→ 2-bromophenylhydrazine hydrochloride (50709-33-6)

Guidance literature:

With hydrogenchloride; acetic acid; sodium nitrite; In water; at 0 ℃; for 1h;

With sodium sulfide; In water; at 60 - 70 ℃; for 1.5h;

With hydrogenchloride; In water; at 60 - 80 ℃; for 12.5h;

upstream raw materials:

2-bromoaniline

Downstream raw materials:

mesoaldehyde 1,3-dioxime-2-(o-bromophenyl)hydrazone

2-Bromobiphenyl

ethyl 7-bromo-1H-indole-2-carboxylate

7-bromotryptamine hydrochloride

Refernces

• 1、 Zhai, Min'an,Wang, Long,Liu, Shiyuan,Wang, Lijing,Yan, Peng,Wang, Junfang,Zhang, Jingbo,Guo, Haifei,Guan, Qi,Bao, Kai,Wu, Yingliang,Zhang, Weige. "Synthesis and biological evaluation of (1-aryl-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone derivatives as tubulin inhibitors". . p. 137 - 147. Retrieved 2018/07/13.
• 2、 -. "Ticyclic compd. and pharmaceutical composition containing the same". Paragraph 0053; 0058. . Retrieved 2016/10/08.