3-PHENYL-1,2,3-TRIAZOLO(1,5-A)PYRIDINE

Base Information

• Chemical Name: 3-PHENYL-1,2,3-TRIAZOLO(1,5-A)PYRIDINE
• CAS No.: 832-81-5
• Molecular Formula: C12H9N3
• Molecular Weight: 195.224
• Hs Code.: 2933990090
• Mol file: 832-81-5.mol

Synonyms:v-Triazolo[1,5-a]pyridine,3-phenyl- (6CI,7CI,8CI);NSC 407329;3-phenyl[1,2,3]triazolo[1,5-a]pyridine;3-phenyltriazolo[1,5-a]pyridine;3-Phenyl-1,2,3-triazolo[1,5-a]pyridine;

Chemical Property of 3-PHENYL-1,2,3-TRIAZOLO(1,5-A)PYRIDINE

Chemical Property:

• Melting Point: 114 C
• Refractive Index: 1.674
• PSA: 30.19000
• Density: 1.21 g/cm³
• LogP: 2.39630

Purity/Quality:

98%min ^*data from raw suppliers

3-Phenyl[1,2,3]triazolo[1,5-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-PHENYL-1,2,3-TRIAZOLO(1,5-A)PYRIDINE

There total 16 articles about 3-PHENYL-1,2,3-TRIAZOLO(1,5-A)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(hydrazono(phenyl)methyl)pyridine (56009-91-7) → 3-phenyl-[1,2,3]triazolo[1,5-a]pyridine (832-81-5)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1080/00397910008087337

Reference yield: 87.0%

phenyl 2-pyridyl ketone hydrazone → 3-phenyl-[1,2,3]triazolo[1,5-a]pyridine (832-81-5)

Guidance literature:

With copper diacetate; In ethyl acetate; at 20 ℃; for 0.333333h; Reagent/catalyst; Solvent; Temperature; Time;

DOI:10.1002/chem.201302997

Reference yield: 82.0%

2-Benzylpyridine (101-82-6) → 3-phenyl-[1,2,3]triazolo[1,5-a]pyridine (832-81-5)

Guidance literature:

2-Benzylpyridine; With n-butyllithium; In diethyl ether; at 0 - 20 ℃; for 2h; Schlenk technique; Inert atmosphere;

With dinitrogen monoxide; In tetrahydrofuran; at 50 ℃; for 2h;

DOI:10.1039/d1cc04907k

upstream raw materials:

2-(hydrazono(phenyl)methyl)pyridine

3-phenyl-[1,2,3]triazolo[1,5-a]pyridin-7-yl pyridin-2-yl methanone

3-iodo-[1,2,3]triazolo[1,5-a]pyridine

phenylboronic acid

Downstream raw materials:

phenyl(pyridin-2-yl)methyl acetate

phenyl(pyridin-2-yl)methyl benzoate

3-phenyl-[1,2,3]triazolo[1,5-a]pyridin-7-yl pyridin-2-yl methanone

phenyl(3-phenyl-[1,2,3]triazolo[1,5-a]pyridin-7-yl)methanol

Refernces

• 1、 Rawat, Deepa,Adimurthy, Subbarayappa. "Transannulation of Pyridotriazoles with Naphthoquinones and Indoles: Synthesis of Benzo[f]Pyrido[1,2-a]Indoles and Indolizino[3,2-b]indoles". . p. 71 - 76. Retrieved 2021/10/29.
• 2、 Landman, Iris R.,Fadaei-Tirani, Farzaneh,Severin, Kay. "Nitrous oxide as a diazo transfer reagent: The synthesis of triazolopyridines". supporting information. p. 11537 - 11540. Retrieved 2021/11/16.