Technology Process of (+/-)-19-exo-(2,6-Difluorobenzyloxy)-1-(4-methoxyphenylsulfonyl)allohobartine
There total 5 articles about (+/-)-19-exo-(2,6-Difluorobenzyloxy)-1-(4-methoxyphenylsulfonyl)allohobartine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) NaH, DMSO / 1) diethyl ether, room temp., 30 min, 2) diethyl ether, room temp., 1 h
3: 1) O3, 2) Me2S / 1) CH2Cl2, -78 deg C, 2) a) -80 deg C, 1 h, b) to room temp.
4: 1) molecular sieves, 4 Angstroem, 2) HCOOH / 1) CHCl3, 3 h, 2) room temp., 48 h
With
formic acid; molecular sieve; dimethylsulfide; 4 A molecular sieve; sodium hydride; ozone; dimethyl sulfoxide;
DOI:10.1002/hlca.19910740804
- Guidance literature:
-
Multi-step reaction with 3 steps
2: 1) O3, 2) Me2S / 1) CH2Cl2, -78 deg C, 2) a) -80 deg C, 1 h, b) to room temp.
3: 1) molecular sieves, 4 Angstroem, 2) HCOOH / 1) CHCl3, 3 h, 2) room temp., 48 h
With
formic acid; molecular sieve; dimethylsulfide; 4 A molecular sieve; ozone;
DOI:10.1002/hlca.19910740804
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1) O3, 2) Me2S / 1) CH2Cl2, -78 deg C, 2) a) -80 deg C, 1 h, b) to room temp.
2: 1) molecular sieves, 4 Angstroem, 2) HCOOH / 1) CHCl3, 3 h, 2) room temp., 48 h
With
formic acid; molecular sieve; dimethylsulfide; 4 A molecular sieve; ozone;
DOI:10.1002/hlca.19910740804
