8-hydroxyacyclovir

Base Information

• Chemical Name: 8-hydroxyacyclovir
• CAS No.: 80685-23-0
• Molecular Formula: C₈H₁₁N₅O₄
• Molecular Weight: 241.206
• Mol file: 80685-23-0.mol

Synonyms:8-Hydroxyacyclovir

Chemical Property of 8-hydroxyacyclovir

Chemical Property:

• Vapor Pressure: 1.94E-15mmHg at 25°C
• Boiling Point: 604°C at 760 mmHg
• Flash Point: 319.1°C
• PSA: 139.54000
• Density: 2.17g/cm³
• LogP: -0.63270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Acyclovir (A192400) is the parent compound for 8-Hydroxyacyclovir. Acyclovir (ACV), an anti-virus drug, was widely detected in natural water at concns. . ranging from ng L-1 to μg L-1 due to inefficient biol. treatments in sewage treatment plant.

Technology Process of 8-hydroxyacyclovir

There total 2 articles about 8-hydroxyacyclovir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

9-<(2-hydroxyethoxy)methyl>-8-bromoguanine (81475-44-7) → 9-<(2-hydroxyethoxy)methyl>-8-hydroxyguanine (80685-23-0)

Guidance literature:

With sodium acetate; In acetic acid; for 3h; Heating;

DOI:10.1021/jm00377a018

Reference yield:

2-amino-9-[(2-hydroxyethoxy)methyl]-9H-purin-6-ol (59277-89-3) → 9-<(2-hydroxyethoxy)methyl>-8-hydroxyguanine (80685-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / Br₂ / H₂O / 2 h / 0 °C

2: 65 percent / NaOAc / acetic acid / 3 h / Heating

With bromine; sodium acetate; In water; acetic acid;

DOI:10.1021/jm00377a018

upstream raw materials:

9-<(2-hydroxyethoxy)methyl>-8-bromoguanine

2-amino-9-[(2-hydroxyethoxy)methyl]-9H-purin-6-ol

Refernces