4-(3-cyanophenyl)-2-cyanopyrimidine

Base Information

• Chemical Name: 4-(3-cyanophenyl)-2-cyanopyrimidine
• CAS No.: 145276-24-0
• Molecular Formula: C₁₂H₆N₄
• Molecular Weight: 206.206
• Mol file: 145276-24-0.mol

Synonyms:4-(3-cyanophenyl)-2-cyanopyrimidine

Chemical Property of 4-(3-cyanophenyl)-2-cyanopyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-cyanophenyl)-2-cyanopyrimidine

There total 6 articles about 4-(3-cyanophenyl)-2-cyanopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

potassium cyanide (151-50-8) + 4-(3-cyanophenyl)-2-(methylsulfonyl)pyrimidine (145276-34-2) → 4-(3-cyanophenyl)-2-cyanopyrimidine (145276-24-0)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 2.5h;

DOI:10.1021/jm00053a007

Reference yield:

4-(3-cyanophenyl)-2-(methylsulfonyl)pyrimidine (145276-34-2) → 4-(3-cyanophenyl)-2-cyanopyrimidine (145276-24-0)

Guidance literature:

In water; N,N-dimethyl-formamide;

Reference yield:

3-acethylbenzonitrile (6136-68-1) → 4-(3-cyanophenyl)-2-cyanopyrimidine (145276-24-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 56.5 percent / 1 h / 110 °C

2: 73.5 percent / KOH / ethanol / 4 h / Heating

3: 73.2 percent / aq. NaOH / H₂O / 12 h / Ambient temperature

4: 80.2 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 12 h

5: 61 percent / dimethylformamide / 2.5 h / 100 °C

With potassium hydroxide; sodium hydroxide; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00053a007

upstream raw materials:

potassium cyanide

4-(3-cyanophenyl)-2-(methylsulfonyl)pyrimidine

3-acethylbenzonitrile

(E)-3-(3-(dimethylamino)acryloyl)benzonitrile

Downstream raw materials:

4-(3-Ethylsulfanylcarbonimidoyl-phenyl)-pyrimidine-2-carboximidothioic acid ethyl ester

4-(3-Thiocarbamoyl-phenyl)-pyrimidine-2-carbothioic acid amide

Refernces

• 1、 -. "Bipyridine compounds". . . Retrieved 2008/06/13.