P-[2-(diphenylphosphino)phenyl]-N,N-diethyl-P-phenylphosphinic amide

Base Information

• Chemical Name: P-[2-(diphenylphosphino)phenyl]-N,N-diethyl-P-phenylphosphinic amide
• CAS No.: 1198339-43-3
• Molecular Formula: C₂₈H₂₉NOP₂
• Molecular Weight: 457.492
• Mol file: 1198339-43-3.mol

Synonyms:P-[2-(diphenylphosphino)phenyl]-N,N-diethyl-P-phenylphosphinic amide

Chemical Property of P-[2-(diphenylphosphino)phenyl]-N,N-diethyl-P-phenylphosphinic amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of P-[2-(diphenylphosphino)phenyl]-N,N-diethyl-P-phenylphosphinic amide

There total 2 articles about P-[2-(diphenylphosphino)phenyl]-N,N-diethyl-P-phenylphosphinic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

N,N-diethyl P,P-diphenylphosphinamide (56372-47-5) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → P-[2-(diphenylphosphino)phenyl]-N,N-diethyl-P-phenylphosphinic amide (1198339-43-3)

Guidance literature:

N,N-diethyl P,P-diphenylphosphinamide; With sec.-butyllithium; In tetrahydrofuran; at -70 - -40 ℃; Inert atmosphere;

chloro-diphenylphosphine; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0029-1216897

Reference yield:

chloro-diphenylphosphine (1079-66-9,74391-44-9) → P-[2-(diphenylphosphino)phenyl]-N,N-diethyl-P-phenylphosphinic amide (1198339-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine

2: N,N,N,N,-tetramethylethylenediamine; n-butyllithium

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; triethylamine;

DOI:10.1021/acscatal.5b01490

Reference yield:

chloromethyl(1,5-cyclooctadiene)palladium(II) + P-[2-(diphenylphosphino)phenyl]-N,N-diethyl-P-phenylphosphinic amide (1198339-43-3) → C29H32ClNOP2Pd

Guidance literature:

In dichloromethane;

DOI:10.1021/acscatal.5b01490

upstream raw materials:

N,N-diethyl P,P-diphenylphosphinamide

chloro-diphenylphosphine

Refernces

• 1、 Williams, D. Bradley G.,Evans, Stephen J.,De Bod, Henriette,Mokhadinyana, Molise S.,Hughes, Tanya. "Directed ortho metallation chemistry and phosphine synthesis: New ligands for the suzuki-miyaura reaction". experimental part. p. 3106 - 3112. Retrieved 2009/12/28.