Aminoguanidine

Base Information

• Chemical Name: Aminoguanidine
• CAS No.: 79-17-4
• Molecular Formula: CH6 N4
• Molecular Weight: 74.0854
• European Community (EC) Number: 201-183-1
• UNII: SCQ4EZQ113
• DSSTox Substance ID: DTXSID5040964
• Nikkaji Number: J5.508E
• Wikipedia: Pimagedine
• Wikidata: Q409583
• NCI Thesaurus Code: C84059
• Pharos Ligand ID: YSTM93VUK59G
• Metabolomics Workbench ID: 52257
• ChEMBL ID: CHEMBL225304
• Mol file: 79-17-4.mol

Synonyms:aminoguanidine;aminoguanidine sulfate;hydrazinecarboximidamide;monoaminoguanidine;pimagedine;pimagedine hydrochloride

Chemical Property of Aminoguanidine

Chemical Property:

• Vapor Pressure: 0.0116mmHg at 25°C
• Melting Point: 182-185 °C (decomp)
• Refractive Index: 1.6660 (estimate)
• Boiling Point: 261.4oC at 760 mmHg
• PKA: 11.08±0.70(Predicted)
• Flash Point: 111.9oC
• PSA: 87.92000
• Density: 1.72g/cm3
• LogP: 0.23440
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 74.059246208
• Heavy Atom Count: 5
• Complexity: 41.6

Purity/Quality:

98%,99%, ^*data from raw suppliers

Pimagedinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(=NN)(N)N
• Recent ClinicalTrials: A Clinical Trial to Evaluate the Safety and Efficacy of 'AG1904' in Acute Bronchitis

Technology Process of Aminoguanidine

There total 38 articles about Aminoguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nitroguanidine (556-88-7) + ammonium hydroxide → N,N'-diaminoguanidine (4364-78-7) + aminoguanidine (79-17-4) + 3-amino-1-nitroguanidine (18264-75-0)

Guidance literature:

DOI:10.1021/ja01161a039

Reference yield:

(2,2,2-trichloro-ethylidenamino)-guanidine; nitrate → chloroform (67-66-3,8013-54-5) + aminoguanidine (79-17-4)

Guidance literature:

Reference yield:

3-amino-1-nitroguanidine (18264-75-0) → nitroguanidine (556-88-7) + aminoguanidine (79-17-4) + hydrazine (302-01-2,78206-91-4,119775-10-9,75013-58-0)

Guidance literature:

Produkt 5: Guanidin;

DOI:10.1177/000348940211100611

upstream raw materials:

CYANAMID

nitrosoguanidine

nitroguanidine

2-methylisothiourea sulphate

Downstream raw materials:

3⁽⁵⁾-amino-1,2,4-triazole

N-(5-phenyl-1H-[1,2,4]triazol-3-yl)-benzamide

N-(benzamido)-guanidine

5-amino-4-phenyl-2,4-dihydro-[1,2,4]triazolidine-3-thione

Refernces

• 1、 Voloshenko Rossin, Anna,Sladkevich, Sergey,Gasser, Guy,Melman, Artem,Lev, Ovadia. "Sensitive Analysis of Nitroguanidine in Aqueous and Soil Matrices by LC-MS". . p. 9990 - 9996. Retrieved 2017.
• 2、 Alexandre-Moreira, Magna S.,Aquino, Pedro G. V.,Bourguignon, Jean-Jacques,Bri-Card, Jacques,Freitas, Johnnatan D.,Meneghetti, Mario R.,Nascimento, Igor J. S.,Queiroz, Aline C.,Rodrigues, Klinger A. F.,Rodrigues, Raiza R. L.,Santos, Mariana S.,Schmitt, Martine,de Aquino, Thiago M.,Araújo, Morgana V.,Fran?a, Paulo H. B.,Rodrigues, érica E. E. S.,Santos-Júnior, Paulo F. S.,da Silva-Júnior, Edeildo F.,de Araújo-Júnior, Jo?o X.. "Synthesis, Antileishmanial Activity and In Silico Studies of Aminoguanidine Hydrazones (AGH) and Thiosemicarbazones (TSC) Against Leishmania chagasi Amastigotes". . p. 151 - 169. Retrieved 2022/02/05.
• 3、 -. "Synthesis of 5 - amino tetrazole method". Paragraph 0028; 0029; 0030. . Retrieved 2019/06/13.