5-Fluorotryptamine

Base Information

• Chemical Name: 5-Fluorotryptamine
• CAS No.: 576-16-9
• Molecular Formula: C10H11FN2
• Molecular Weight: 178.209
• Hs Code.: 2933990090
• Mol file: 576-16-9.mol

Synonyms:Indole,3-(2-aminoethyl)-5-fluoro- (6CI,7CI,8CI);2-(5-Fluoro-1H-indol-3-yl)ethylamine;2-(5-Fluoroindol-3-yl)ethylamine;

Chemical Property of 5-Fluorotryptamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 273-275 °C
• Refractive Index: 1.324
• Boiling Point: 345.959 °C at 760 mmHg
• PKA: 16.37±0.30(Predicted)
• Flash Point: 163.03 °C
• PSA: 41.81000
• Density: 1.25 g/cm³
• LogP: 2.50850

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Fluorotryptamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluorotryptamine

There total 21 articles about 5-Fluorotryptamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-fluoro-3-(2-nitrovinyl)indole (208645-53-8) → 5-fluorotryptamine (576-16-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 40h;

DOI:10.1002/anie.201310905

Reference yield: 76.0%

(Ε)-5-fluoro-3-(2-nitroethenyl)-1Η-indole (214417-26-2) → 5-fluorotryptamine (576-16-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ja9024885

Reference yield: 41.0%

DL-5-fluorotryptophan (154-08-5,343-91-9,97749-24-1) → 5-fluorotryptamine (576-16-9)

Guidance literature:

With pyridoxal 5'-phosphate; aromatic L-amino acid decarboxylase; In various solvent(s); at 30 ℃; for 48h;

upstream raw materials:

3-(2-amino-ethyl)-5-fluoro-indole-2-carboxylic acid

4-aminobutyrylaldehyde diethylacetal

4-fluorophenylhydrazine

DL-5-fluorotryptophan

Downstream raw materials:

N-(p-Nitrobenzyloxycarbonyl)-5-fluorotryptamine

N,N-Dimethyl-5-fluoro-1H-indole-3-ethanamine

Refernces

• 1、 Xiong, Runde,He, Dongxiu,Deng, Xiangping,Liu, Juan,Lei, Xiaoyong,Xie, Zhizhong,Cao, Xuan,Chen, Yanming,Peng, Junmei,Tang, Guotao. "Design, synthesis and biological evaluation of tryptamine salicylic acid derivatives as potential antitumor agents". . p. 573 - 583. Retrieved 2019/04/30.
• 2、 -. "Indole derivative and uses thereof". Paragraph 0236; 0237. . Retrieved 2017/09/01.