Promethazine HCI

Base Information

• Chemical Name: Promethazine HCI
• CAS No.: 58-33-3
• Molecular Formula: C17H20N2S.HCl
• Molecular Weight: 320.886
• Hs Code.: 29343000
• Mol file: 58-33-3.mol

Synonyms:Promethazine HCI;AKOS015914197;(+/-)-10-[2-(Dimethylamino)propyl]phenothiazine HCl

Chemical Property of Promethazine HCI

Chemical Property:

• Appearance/Colour: white to faint yellow crystalline powder
• Melting Point: 230-232°C
• Boiling Point: 403.7 °C at 760 mmHg
• Flash Point: 198 °C
• PSA: 31.78000
• Density: 1.131 g/cm3
• LogP: 5.10640
• Storage Temp.: Refrigerator
• Solubility.: Very soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 320.1113975
• Heavy Atom Count: 21
• Complexity: 298

Purity/Quality:

99% ^*data from raw suppliers

Promethazine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,N
• Statements: 22-36/37/38-51/53-43-20/22
• Safety Statements: 26-36-61-60-36/37/39-28-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [H+].CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.[Cl-]
• Indications: PM is used for the treatment of allergic symptoms, often given at night because of its marked sedative effects. Drug hypersensitivity reactions and allergic conditions have also been treated with promethazine especially in emergencies. It can also be used in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections; in fact, inhalation therapy for relieving bronchial spasm is made by quaternary salts of promethazine. PM is sometimes used for its sedative effects and in some countries is marketed for this purpose, including the sedation of young children as nasal sleep introducing drug, or it can be used as an anaesthetic premedication to produce sedation, reduce anxiety, or to reduce postoperative nausea and vomiting as dose-controlled transdermal device. The drug is often given in conjunction with an opiate analgesic such as pethidine, particularly in obstetrics. Taken before travelling, promethazine is effective in preventing motion sickness. Vomiting from other causes can be treated with higher or more frequent doses. Combination of histamine H1R and H4R antagonist is used for the treatment of neoplastic disorders, consisting in a cytotoxic agent as an agent to prevent multidrug resistance[9]. It is also used as a contraceptive killing spermin vagina, since promethazine hydrochloride has strong sperm-killing effect, or as an antimutagenic treatment of bacteria by killing bacteria. Bathing preparation, which contains a histamine H1-antagonist, inhibits the decomposition of hyaluronic acid, playing an important role inmoisture and tension of skin to improve roughened or dried skin. This cosmetic can take such a form as gel, cream, spray, cataplasm, lotion, pack, milky lotion, or powder. It can also be a melanogenesis-suppressing agent useful as a skin-beautifying cosmetic, a skin-aging prevention agent, and so forth, by using a phenothiazine compound having remarkable melanogenesis-suppressing effect. Application of PM can be used for treating haemorrhoids with no pain, no side effect, no operation, and no hospitalization, but low cost[10–12]. Promethazine has been used to control extrapyramidal disorders in children caused by metoclopramide and levodopa-induced dyskinesia in patients with Parkinson’s disease. In young children undergoing dental procedures, it has been suggested that promethazine can be used in conjunction with chloral hydrate to produce sedation, as there was observed a lower incidence of nausea than when chloral hydrate was administered alone. In some countries, promethazine is available as a 2% cream without medical prescription for the treatment of allergic skin conditions, insect bites, and burns.
• Uses: stool softener For the treatment of allergic disorders, and nausea/vomiting. Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively. Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM). Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea. Promethazine hydrochloride is used as antihistamine; antiemetic; central nervous system depressant; sedative; anticholinergic; antiserotoninergic; local anesthetic; in the treatment of motion sickness, cough linctuses, nausea, and allergic conditions; used to control Parkinsonian symptoms and as central nervous system depressant; in pills, syrup, injections and suppositories.
• Clinical Use: Antihistamine
• Drug interactions: Potentially hazardous interactions with other drugs Analgesics: possibly increased sedative effects.

Technology Process of Promethazine HCI

There total 1 articles about Promethazine HCI which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ phenergan (58-33-3)

Guidance literature:

aus Aminochlorpropan u. Phenothiazin;

Reference yield: 96.0%

phenergan (58-33-3) → 10-[2-(dimethylamino)propyl]phenothiazine (60-87-7)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; Reagent/catalyst;

Reference yield:

phenergan (58-33-3) → thiazinamium metilsulfate (58-34-4)

Guidance literature:

With dimethyl sulfate; In acetone;

Downstream raw materials:

N-Demethylpromethazine

10-[2-(dimethylamino)propyl]phenothiazine

thiazinamium metilsulfate

C₂₃H₃₂N₂O₃S

Refernces