isocytidine

Base Information

• Chemical Name: isocytidine
• CAS No.: 489-59-8
• Molecular Formula: C9H13 N3 O5
• Molecular Weight: 243.219
• Mol file: 489-59-8.mol

Synonyms:Isocytidine(6CI,8CI)

Chemical Property of isocytidine

Chemical Property:

• Vapor Pressure: 3.5E-14mmHg at 25°C
• Boiling Point: 545.7°Cat760mmHg
• Flash Point: 283.8°C
• PSA: 131.82000
• Density: 1.89g/cm³
• LogP: -2.22060

Purity/Quality:

98%min ^*data from raw suppliers

Isocytidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An isomer of Cytidine (C998300); a constituent of nucleic acid. It is converted to isocytosine and uracil during metabolism in Escherichia coli.

Technology Process of isocytidine

There total 2 articles about isocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-1-β-D-ribofuranosyl-pyrimidine-4-one (53337-88-5) → CYTIDINE (65-46-3) + 2-amino-1-(β-D-ribofuranosyl)pyrimidin-4(1H)-one (489-59-8)

Guidance literature:

With ammonia; at 20 ℃; Product distribution; half-time;

Reference yield:

4-methoxy-1-β-D-ribofuranosyl-1H-pyrimidin-2-one (34218-77-4) → CYTIDINE (65-46-3) + 2-amino-1-(β-D-ribofuranosyl)pyrimidin-4(1H)-one (489-59-8)

Guidance literature:

With ammonia; at 20 ℃; Product distribution; half-time;

Reference yield: 50.0%

2,2-dimethoxy-propane (77-76-9) + 2-amino-1-(β-D-ribofuranosyl)pyrimidin-4(1H)-one (489-59-8) → 2',3'-O-Isopropyliden-isocytidin (5975-05-3)

Guidance literature:

With toluene-4-sulfonic acid; for 2h; Ambient temperature;

DOI:10.1246/bcsj.53.3670

upstream raw materials:

2-methoxy-1-β-D-ribofuranosyl-pyrimidine-4-one

4-methoxy-1-β-D-ribofuranosyl-1H-pyrimidin-2-one

Downstream raw materials:

2',3'-O-Isopropyliden-isocytidin

Refernces