7-Fluoro-n-hydroxy-n-2-acetylaminofluorene

Base Information

• Chemical Name: 7-Fluoro-n-hydroxy-n-2-acetylaminofluorene
• CAS No.: 2508-18-1
• Molecular Formula: C₁₅H₁₂FNO₂
• Molecular Weight: 257.264
• Hs Code.: 2924299090
• NSC Number: 46523
• UNII: D8S2LZL9A3
• DSSTox Substance ID: DTXSID40179769
• Nikkaji Number: J74.809I
• Wikidata: Q83050293
• ChEMBL ID: CHEMBL35220
• Mol file: 2508-18-1.mol

Synonyms:7-fluoro-N-hydroxy-N-2-acetylaminofluorene

Chemical Property of 7-Fluoro-n-hydroxy-n-2-acetylaminofluorene

Chemical Property:

• Vapor Pressure: 3.39E-09mmHg at 25°C
• Boiling Point: 458.4°Cat760mmHg
• Flash Point: 231°C
• PSA: 40.54000
• Density: 1.389g/cm³
• LogP: 3.13900
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 257.08520679
• Heavy Atom Count: 19
• Complexity: 362

Purity/Quality:

99% ^*data from raw suppliers

7-FLUORO-N-HYDROXY-N-2-ACETYLAMINOFLUORENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N(C1=CC2=C(C=C1)C3=C(C2)C=C(C=C3)F)O

Technology Process of 7-Fluoro-n-hydroxy-n-2-acetylaminofluorene

There total 1 articles about 7-Fluoro-n-hydroxy-n-2-acetylaminofluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-7-nitro-fluorene (1806-25-3) + acetyl chloride (75-36-5) → 7-fluoro-N-hydroxy-2-acetamidofluorene (2508-18-1)

Guidance literature:

With sodium hydrogencarbonate; ammonium chloride; zinc; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 1.5 h, 2.) Et₂O, 0 deg C, 1 h;

DOI:10.1021/jm00379a005

Reference yield: 66.0%

acetic anhydride (108-24-7) + 7-fluoro-N-hydroxy-2-acetamidofluorene (2508-18-1) → 7-fluoro-2-(N-acetoxyacetamido)fluorene (6344-58-7)

Guidance literature:

In pyridine; for 0.75h; Ambient temperature;

DOI:10.1021/jm00148a014

Reference yield:

7-fluoro-N-hydroxy-2-acetamidofluorene (2508-18-1) → 3-(methylthio)-7-fluoro-2-aminofluorene (16233-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / pyridine / 0.75 h / Ambient temperature

2: 1.) 0.1 M phosphate buffer (pH=7.8), 2.) 7 N aq. HCl / 1.) 95percent aq. ethanol, 48 deg C, 2.5 h, 2.) reflux, 8 h

With hydrogenchloride; phosphate buffer; In pyridine;

DOI:10.1021/jm00148a014

upstream raw materials:

2-fluoro-7-nitro-fluorene

acetyl chloride

Downstream raw materials:

7-fluoro-2-(N-acetoxyacetamido)fluorene

3-(methylthio)-7-fluoro-2-aminofluorene

1-(methylthio)-7-fluoro-2-aminofluorene

1-(methylthio)-7-fluoro-2-acetamidofluorene

Refernces