α-tert-butyl N^α-Boc-N^α'-Cbz-α,α'-diaminosuberate

Base Information

• Chemical Name: α-tert-butyl N^α-Boc-N^α'-Cbz-α,α'-diaminosuberate
• CAS No.: 63061-86-9
• Molecular Formula: C₂₅H₃₈N₂O₈
• Molecular Weight: 494.585
• Mol file: 63061-86-9.mol

Synonyms:α-tert-butyl N^α-Boc-N^α'-Cbz-α,α'-diaminosuberate

Chemical Property of α-tert-butyl N^α-Boc-N^α'-Cbz-α,α'-diaminosuberate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of α-tert-butyl N^α-Boc-N^α'-Cbz-α,α'-diaminosuberate

There total 1 articles about α-tert-butyl N^α-Boc-N^α'-Cbz-α,α'-diaminosuberate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-L-GluOMe (5672-83-3) + N-tert-butoxycarbonyl glutamic acid tert-butyl ester (24277-39-2) → (S,S)-2,7-bis<<(benzyloxy)carbonyl>amino>octanedioic acid (157886-31-2) + di-tert-butyl-di-Boc-diaminosuberate (73872-73-8) + α-tert-butyl Nα-Boc-Nα'-Cbz-α,α'-diaminosuberate (63061-86-9)

Guidance literature:

With sodium hydroxide; Yield given. Multistep reaction. Yields of byproduct given; 1) electrolyse, MeOH, pyridine, 20-25 deg C, 55 min, 2) 25 deg C, 15 min;

DOI:10.1021/jo01303a028

Reference yield:

α-tert-butyl Nα-Boc-Nα'-Cbz-α,α'-diaminosuberate (63061-86-9) + Phe-D-Trp-Lys(iNoc)-Thr(OBz)-OMe 2HCl → C70H87N9O16

Guidance literature:

With TEA; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; for 2h; Yield given; Ambient temperature;

DOI:10.1021/ja00541a025

upstream raw materials:

Z-L-GluOMe

N-tert-butoxycarbonyl glutamic acid tert-butyl ester

Refernces