N-methyl-N-(2-(methylthio)phenyl)acetamide

Base Information

• Chemical Name: N-methyl-N-(2-(methylthio)phenyl)acetamide
• CAS No.: 91799-47-2
• Molecular Formula: C₁₀H₁₃NOS
• Molecular Weight: 195.285
• Mol file: 91799-47-2.mol

Synonyms:N-methyl-N-(2-(methylthio)phenyl)acetamide

Chemical Property of N-methyl-N-(2-(methylthio)phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of N-methyl-N-(2-(methylthio)phenyl)acetamide

There total 9 articles about N-methyl-N-(2-(methylthio)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

o-(N,N-dimethylamino)phenyl methyl thioether (2388-50-3) + acetic anhydride (108-24-7) → N-methyl-N-(2-(methylthio)phenyl)acetamide (91799-47-2)

Guidance literature:

With oxygen; copper diacetate; at 100 ℃; for 36h; Schlenk technique; Sealed tube;

DOI:10.1039/c5cc07454a

Reference yield: 73.0%

2-Methylbenzothiazole (120-75-2) + dimethylsulfite (616-42-2) → N-methyl-N-(2-(methylthio)phenyl)acetamide (91799-47-2)

Guidance literature:

With N,N-dimethyl acetamide; iodine; sodium ethanolate; In water; at 80 ℃; for 24h; Schlenk technique;

DOI:10.1039/d0cc08096a

Reference yield:

N-(2-iodophenyl)-N-methylacetamide (90585-26-5) + methyl iodide (74-88-4) → N-acetyl-N-methylaniline (579-10-2) + N-methyl-N-(2-(methylthio)phenyl)acetamide (91799-47-2)

Guidance literature:

N-(2-iodophenyl)-N-methylacetamide; With potassium tert-butylate; thiourea; In dimethyl sulfoxide; for 3h; Inert atmosphere; Irradiation;

methyl iodide; In dimethyl sulfoxide;

DOI:10.1021/jo801892c

upstream raw materials:

N-methyl-o-aminophenyl methyl sulphide

2-methylmercaptobenzothiazole

2-Imino-3-methylbenzothiazolin

3-methyl-(3H)benzothiazolone

Downstream raw materials:

N-methyl-o-aminophenyl methyl sulphide

Refernces

• 1、 Cheng, Hui-Cheng,Hou, Wen-Jun,Li, Zeng-Wen,Liu, Ming-Yu,Guan, Bing-Tao. "The copper-catalyzed aerobic oxidative amidation of tertiary amines". supporting information. p. 17596 - 17599. Retrieved 2015/12/08.