1-AMINO-3,3-DIETHOXYPROPANE

Base Information

• Chemical Name: 1-AMINO-3,3-DIETHOXYPROPANE
• CAS No.: 41365-75-7
• Molecular Formula: C7H17NO2
• Molecular Weight: 147.217
• Hs Code.: 2922199090
• Mol file: 41365-75-7.mol

Synonyms:3,3-Diethoxy-1-propanamine;3,3-Diethoxypropylamine;3-AMINOPROPIONALDEHYDE DIETHYL ACETAL;3,3-DIETHOXY-1-PROPYLAMINE;1-AMINO-3,3-DIETHOXYPROPANE;APEA;RARECHEM AL BW 0123;TIMTEC-BB SBB005781

Chemical Property of 1-AMINO-3,3-DIETHOXYPROPANE

Chemical Property:

• Appearance/Colour: clear colourless to yellow liquid
• Vapor Pressure: 0.321mmHg at 25°C
• Refractive Index: 1.4233-1.4253
• Boiling Point: 200.6 °C at 760 mmHg
• PKA: 8.92±0.13(Predicted)
• Flash Point: 79.3 °C
• PSA: 44.48000
• Density: 0.915 g/cm³
• LogP: 1.43460
• Storage Temp.: room temp
• Sensitive.: Air Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-?Amino-?3,?3-?Diethoxypropane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Amino-3,3-diethoxypropane has been used:with alginate in the preparation of hydrogelin the generation of polyethylene glycol (PEG) polyethylenimine (PEI) polyplexes conjugate for transfection studies in hepatocellular carcinoma cell culturesas a component of pH-sensitive PEG derivative for lipopolyplexes formation

Technology Process of 1-AMINO-3,3-DIETHOXYPROPANE

There total 11 articles about 1-AMINO-3,3-DIETHOXYPROPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-nitropropanal diethyl acetal (107833-73-8) → aminopropane diethyl acetal (41365-75-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 7600.51 Torr;

DOI:10.1016/j.tetasy.2012.12.009

Reference yield: 87.0%

N-(3,3-diethoxypropyl)phthalimide (2453-90-9) → aminopropane diethyl acetal (41365-75-7)

Guidance literature:

With hydrazine; In methanol; for 2h; Heating;

DOI:10.1002/jhet.5570180519

Reference yield: 49.0%

3,3-bis(ethyloxy)propanenitrile (2032-34-0) → aminopropane diethyl acetal (41365-75-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 16h; Ambient temperature;

DOI:10.1002/ardp.19953280604

upstream raw materials:

3-chloro-1,1-diethoxy-propane

3,3-diethoxypropionic amide

N-(3,3-diethoxypropyl)phthalimide

3,3-bis(ethyloxy)propanenitrile

Downstream raw materials:

[(S)-1-(3,3-Diethoxy-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

N-(3,3-diethoxypropyl)benzylamine hydrochloride

3-fluoro-N-(3,3-diethoxypropyl)benzylamine hydrochloride

C₁₇H₂₉NO₄

Refernces

• 1、 Xun, Jin,Huang, Haidong,Vogel, Kurt W.,Drueckhammer, Dale G.. "The importance of the amide bond nearest the thiol group in enzymatic reactions of coenzyme A". . p. 90 - 107. Retrieved 2007/10/03.
• 2、 Wunsch,Zott,Hofner,Bauschke. "Tricyclic CNS active agents by intramolecular Oxa-Pictet-Spengler reaction". . p. 487 - 495. Retrieved 2007/10/02.